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Synlett 1998; 1998(10): 1147-1149
DOI: 10.1055/s-1998-1891
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A New Approach to Asymmetric Synthesis of β-Amino Alcohols by Means of α-Chirally Protected Amino Alkyllithiums

Takahiro Tomoyasu* , Katsuhiko Tomooka, Takeshi Nakai
  • *Nutrition Research Institute, Otsuka Pharmaceutical Factory, Inc., Muya-cho, Naruto, Tokushima 772, Japan; Fax + 81-3-5734-2885; E-mail: takeshi@o.cc.titech.ac.jp
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Publication Date:
31 December 2000 (online)

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A new, general synthetic approach to enantiopure α-amino ketones and syn-β-amino alcohols is described which employs the doubly chiral N-protected α-amino alkyllithiums generated via Pearson's transmetalative protocol as the key synthetic intermediates.

chiral α-amino alkyllithium - asymmetric synthesis - β-amino alcohol - α-amino ketone