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Synlett 1998; 1998(12): 1432-1434
DOI: 10.1055/s-1998-1970
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A Synthesis of Theopederin D and a Formal Synthesis of Pederin

Philip J. Kocienski* , Robert Narquizian, Piotr Raubo, Christopher Smith, F. Thomas Boyle
  • *Department of Chemistry, Glasgow University, Glasgow G12 8QQ, UK
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Publication Date:
31 December 2000 (online)

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Theopederin D, a cytotoxic metabolite from a sponge of the genus Theonella, was synthesised in 14 steps (11.1% overall yield) from two advanced intermediates previously used in a synthesis of mycalamide B. A formal synthesis of pederin from similar intermediates is also reported.

antitumour - conjugate addition - asymmetric dihydroxylation - Curtius rearrangement - pederin - theopederin D