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Synlett 1998; 1998(12): 1405-1407
DOI: 10.1055/s-1998-1971
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Solid-Phase Synthesis of 3H-Quinazolin-4-ones Based on an Aza Wittig-Mediated annulation Strategy

José M. Villalgordo* , Daniel Obrecht, Alexander Chucholowsky
  • *Pharma Research. F. Hoffmann-La Roche AG, CH-4002 Basel, Switzerland; Fax + 34 972 418 150; E-mail: dqjvs@xamba.udg.es
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Publication History

Publication Date:
31 December 2000 (online)

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Aza Wittig-mediated annulation provides a highly efficient and straightforward strategy for the parallel synthesis of 3H-quinazolin-4-ones on solid support. The products were recovered in good yields and exhibited excellent purities.

solid-phase synthesis - polymer-bound carbodiimides - quinazolinone library - aza Wittig-mediated cyclization - multidirectional cleavage