General Synthesis of Unsymmetrical Tetrasubstituted Oxamides via 1,1′-(1,2-Dioxoethane-1,2-diyl)bis-1H-benzotriazole

Alan R. Katritzky; Julian R. Levell; David P. M. Pleynet

doi:10.1055/s-1998-2020

Synthesis 1998; 1998(2): 153-156
DOI: 10.1055/s-1998-2020

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General Synthesis of Unsymmetrical Tetrasubstituted Oxamides via 1,1′-(1,2-Dioxoethane-1,2-diyl)bis-1H-benzotriazole

Alan R. Katritzky^* , Julian R. Levell, David P. M. Pleynet

^*Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA; Fax + 1(3 52)3 92 91 99; E-mail: KATRITZKY@chem.ufl.edu

Abstract

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Aliphatic, alicyclic, and aromatic secondary amines are converted by 1,1′-(1,2-dioxoethane-1,2-diyl)bis-1H-benzotriazole, in a two-step process, into unsymmetrical tetrasubstituted oxamides in good yields. 1,1′-(1,2-Dioxoethane-1,2-diyl)bis-1H-benzotriazole is available in high yield from benzotriazole and oxalyl chloride.

unsymmetrical - tetrasubstituted - oxamides - benzotriazole

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