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Synlett 1999; 1999(3): 366-374
DOI: 10.1055/s-1999-2612
new tools in synthesis
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Discovery of New Multi Component Reactions with Combinatorial Methods

Lutz Weber* , Katrin Illgen, Michael Almstetter
  • *Morphochem AG, Am Klopferspitz 19, D-82152 Martinsried, Germany
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Publication Date:
31 December 1999 (online)

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The discovery of novel chemical reactions or reaction sequences that are able to generate useful chemical products may be regarded as the heart of organic chemistry. We present here concepts and methods on how to find and explore new multi component reactions, especially with automated combinatorial methods. This "combinatorial reaction finding" provides also a powerful tool to the understanding of the rules of organic chemistry, especially structure-reactivity relationships.

multi component reaction - combinatorial chemistry - synthetic strategy - reaction design