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Synlett 1999; 1999(4): 480-482
DOI: 10.1055/s-1999-2631
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Enantioselective Synthesis of anti 1,3-Diols via Ru(II)-Catalyzed Hydrogenations

Delphine Blanc* , Virginie Ratovelomanana-Vidal, Angela Marinetti, Jean-Pierre Genêt
  • *Laboratoire de Synthèse Sélective Organique et Produits Naturels (UMR 7573), Ecole Nationale Supérieure de Chimie de Paris, 11 rue P. et M. Curie, 75231 Paris Cedex 05, France; Fax 01 44 07 10 62; E-mail: genet@ext.jussieu.fr
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Publication History

Publication Date:
31 December 1999 (online)

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The homogeneous ruthenium-catalyzed hydrogenation of new symmetrical 1,3-diketones has been achieved with various ligands including SKEWPHOS and Me-DuPHOS. Complete conversions with enantiomeric and diastereomeric excesses up to 99% were obtained. This represents a new catalytic application of the chiral ligands above.

1,3-diols - enantioselective hydrogenation - ruthenium catalysts