Download PDF
Synlett 1999; 1999(8): 1181-1190
DOI: 10.1055/s-1999-2791
account
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Insoluble Polymer-Bound (IPB) Approach to the Catalytic Asymmetric Dihydroxylation of Alkenes

Piero Salvadori* , Dario Pini, Antonella Petri
  • *Centro di Studio del C.N.R. per le Macromolecole Sterordinate ed Otticamente Attive, Dipartimento Di chimica e Chimica Industriale, Università di Pisa, Via Risorgimento 35, 56126 Pisa, Italy; Fax +39-0 50-91 82 60; E-mail: psalva@dcci.unipi.it
Further Information

Publication History

Publication Date:
31 December 1999 (online)

  PDF Download  Permissions and Reprints All articles of this category

Asymmetric dihydroxylation induced by Insoluble Polymer-Bound (IPB approach) Cinchona alkaloid derivatives is reviewed. Reactivities and enantioselectivities comparable to those achieved with the soluble counterparts are obtained with polymers having structural properties compatible with the reaction conditions. By using a highly efficient polymer, olefins with different structures can be dihydroxylated at a synthetically useful level of enantioselectivity. Handling and recovery of the catalyst is very easy; recycling is performed with a small amount of metal.

asymmetric synthesis - enantioselective dihydroxylation - heterogeneous catalysis - polymeric chiral ligands - optically active diols