Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000083.xml
Synlett 1999; 1999(10): 1624-1626
DOI: 10.1055/s-1999-2888
DOI: 10.1055/s-1999-2888
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Stereocontrolled Preparation of the C1-C14 Polyene Fragment of Benzenic Ansamycin Antibiotics Ansatrienin A and B
Further Information
Publication History
Publication Date:
31 December 1999 (online)
A practical synthesis of the C1-C14 polyene unit 5 in ansatrienin A (mycotrien I), 1a, and other ansamycin antibiotics is described which involves elaboration of the chiral unsaturated aldehyde 6 and phosphonate 7, followed by coupling of the building blocks by Horner-Emmons-olefination and Duthaler's aldolation. The synthesis of 6 successfully applies two consecutive Evans-aldol reactions for constructing the carbon backbone.
Evans-aldolation - Horner-Emmons olefination - macrolactam antibiotic