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Synlett 1999; 1999(12): 1993-1995
DOI: 10.1055/s-1999-2998
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A New Quinazoline Synthesis

Hiyoshizo Kotsuki* , Hiromitsu Sakai, Hanae Morimoto, Hitoshi Suenaga
  • *Laboratory of Natural Product Synthesis, Faculty of Science, Kochi University, Akebono-cho, Kochi 780-8520, Japan; Fax + 81-88-8 44-83 60; E-mail: kotsuki@cc.kochi-u.ac.jp
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Publication Date:
31 December 1999 (online)

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Condensation of cyano- and nitro-activated o-fluorobenzaldehydes with amidines took place in refluxing acetonitrile in the presence of K2CO3 and powdered molecular sieves 4A to give a variety of quinazoline derivatives in good yields.

quinazolines - amidines - o-fluorobenzaldehydes - SNAr