Download PDF
Synthesis 2000; 2000(7): 1004-1008
DOI: 10.1055/s-2000-6298
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Rapid and Stereoselective C-C, C-O, C-N and C-S Couplings via Microwave Accelerated Palladium-Catalyzed Allylic Substitutions

Ulf Bremberg* , Serghey Lutsenko, Nils-Fredrik Kaiser, Mats Larhed, Anders Hallberg, Christina Moberg
  • *Department of Chemistry, Organic Chemistry, Royal Institute of Technology, SE-100 44 Stockholm, Sweden; Fax +46(8)7912333; E-mail: kimo@orgchem.kth.se
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Palladium-catalyzed substitution of cyclohex-2-en-1-yl ethyl carbonate with neutral C-, O-, and N-nucleophiles was achieved in 1 - 2 minutes using microwave flash heating. Enantioselectivities up to 96% were observed. Ionic nucleophiles tended to result in lower ee. With S-nucleophiles problems with the stability of the nucleophile were encountered.

palladium - catalysis - enantioselective - microwave - phosphine - allylation - ligands