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Synthesis 2000; 2000(8): 1101-1108
DOI: 10.1055/s-2000-6315
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Synthesen und chemische Reaktionen von 1-Cyano-1-isocyanoalkylphosphonsäureestern

Joachim R. Simon* , Richard Neidlein
  • *Pharmazeutisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany; Fax +49 (62 21) 9 54 64 30; E-mail: richard.neidlein@urz.uni-heidelberg.de
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Publication Date:
31 December 2000 (online)

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1-Cyano-1-isocyanoalkylphosphonic acid esters 4 were synthesized starting from cyanoalkyl-phosphonic acid esters 1 by amination and formylation followed by dehydration with trichloromethylchloroformate (diphosgene) and triethylamine at low temperatures. Bromination of 4 gave 1,1-(dibromomethylideneamino)-1-cyanophosphonic acid esters 5.

1-cyano-1-isocyanoalkylphosphonic acid esters - 1,1-(dibromomethylideneamino)-1-cyanophosphonic acid esters - Ugi-reaction