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Synthesis 2000; 2000(4): 561-564
DOI: 10.1055/s-2000-6378
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A Practical Method for the Reformatsky Reaction of Aldehydes

Angshuman Chattopadhyay* , Avinash Salaskar
  • *Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai-400085, India; Fax +91 (22) 5 50 51 51; E-mail: achat@apsara.barc.ernet.in
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Publication Date:
31 December 2000 (online)

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Reformatsky reaction of aliphatic aldehydes has been performed successfully by the addition of BF3 · OEt2 to a stirred suspension of aldehyde, bromo ester and Zn dust in aqueous THF. For aromatic aldehydes, addition of benzoyl peroxide is also required to effect the reaction.

aqueous condition - boron trifluoride etherate - stereoselectivity - chemoselectivity - radical chain mechanism