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Synthesis 2000; 2000(5): 637-639
DOI: 10.1055/s-2000-6383
short paper
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An Efficient Preparation of Macrocycles Bearing Vinamidine Moieties by the Cyclocondensation of Malonaldehyde Derivatives and 1,ω-Diaminoalkanes

Shinji Takamura* , Takanori Yoshimiya, Shinobu Kameyama, Akiko Nishida, Hidetoshi Yamamoto, Michihiko Noguchi
  • *Department of Applied Chemistry, Faculty of Engineering, Yamaguchi University, Tokiwadai, Ube 755-8611, Japan; Fax + 81(836)25 99 33; E-mail: noguchi@po.cc.yamaguchi-u.ac.jp
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Publication Date:
31 December 2000 (online)

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An efficient preparation of macrocycles 7 and 9 bearing vinamidine moieties is described. The key to the preparation is the (2:2) cyclocondensation of malonaldehyde derivatives 1 and 8 and 1,ω-diaminoalkanes 6.

macrocycle - vinamidine - cyclocondensation - malonaldehyde - 1,ω-diaminoalkane