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Synthesis 2000; 2000(5): 643-645
DOI: 10.1055/s-2000-6395
short paper
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Synthesis of New 4-Cyclohexylcoumarin Derivatives

Yagamare Fall* , Carmen Terán, Marta Teijeira, Lourdes Santana, Eugenio Uriarte
  • *Departamento de Química Física y Química Orgánica, Facultad de Ciencias, Universidad de Vigo, Spain; Fax + 34(981)59 49 12; E-mail: qolsant@usc.es
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Publication Date:
31 December 2000 (online)

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4-Cyclohexyl-7-hydroxycoumarin (3) and 4-cyclohexyl-6-hydroxycoumarin (8) have been synthesized and used as key intermediates to prepare the potential antipsychotics 10 and 11 by coupling with a piperazine derivative.

4-cyclohexylcoumarins - arylpiperazines - Wittig reaction - Reformatsky reaction - cyclization - heterocycles