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Synthesis 2000; 2000(9): 1214-1216
DOI: 10.1055/s-2000-6414
short paper
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Efficient Synthesis of 1-Benzyloxyphenyl-3-phenylacetones

Els Mannekens, Dirk Tourwé, William D. Lubell
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Publication Date:
31 December 2000 (online)

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1-[(Benzyloxy)phenyl]-3-phenylacetones 1a - c have been conveniently synthesized by acylation of the PhCH2Li-DAB-CO complex with their respective N-methyl O-methyl hydroxamates 5a - c. In four steps, ketones 1a - c having ortho-, meta- and para-benzyloxy substituents were obtained in 42-51% overall yields from commercially available 2-(hydroxyphenyl)acetic acids.

ketones - N-methoxy-N-methylamides - benzyllithium - acylation - 1-[(benzyloxy)phenyl]-3-phenylacetone