Download PDF
Synlett 2000; 2000(1): 45-48
DOI: 10.1055/s-2000-6446
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Solid Phase Synthesis of Substituted 2,3-Dihydroquinolin-4-ones

Sebastian Wendeborn*
  • *Novartis Crop Protection AG, Basel, Switzerland; Fax + 41-61-697-5500; E-mail: sebastian.wendeborn@cp.novartis.com
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

A highly flexible method for solid phase synthesis of substituted 2,3-dihydroquinolin-4-ones has been developed. Two points of diversity can be introduced through the use of Grignard reagents and amines; a third position can be modified through two novel, oxidative cleavage reactions. Most compounds are obtained in purities exceeding 85%.

combinatorial chemistry - polystyrene - Grignard addition to quinolines - urea formation - enol ether fluorination - enol ether epoxidation