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Synlett 2000; 2000(3): 424-426
DOI: 10.1055/s-2000-6517
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A Versatile Multi-Component One-Pot Thiazole Synthesis

Stefan Heck* , Alexander Dömling
  • *Technical University Munich, Lichtenbergstr. 4, D-85747 Garching, Germany; Fax +49 89 78 00 55 55; E-mail: alexander.doemling@morphochem.de
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Publication History

Publication Date:
31 December 2000 (online)

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A new multi-component reaction (MCR) of oxo components, primary amines, thiocarboxylic acids and a special isocyanide yielding 2,4-disubstituted thiazoles is described. This one-pot, one-step reaction is an alternative to current methods of thiazole ring formation and can be applied to combinatorial chemistry as well as in the total synthesis of thiazole containing natural products.

multi-component reaction - one-pot synthesis - isocyanide - thiocarboxylic acid - thiazole - combinatorial chemistry