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Synlett 2000; 2000(5): 0737-0739
DOI: 10.1055/s-2000-6626
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A Modified Suzuki Reaction of 1,1-Dibromo-1-alkenes

Wang Shen*
  • *Cancer Research, Pharmaceutical Products Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA; Fax + 1(847)935-5165; E-mail: wang.shen@abbott.com
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Publication Date:
31 December 2000 (online)

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The (E)-bromides in 1,1-dibromo-1-alkenes were stereoselectively coupled with aryl- or alkenylboronic acids to give the corresponding (Z)-1-Aryl(alkenyl)-1-bromo-1-alkenes. Tris(2-furyl)phosphine (TFP) was used as the ligand to palladium, and the combination of 1,4-dioxane and aqueous sodium carbonate produced the best results.

alkenes - coupling - palladium - Suzuki reaction - stereoselectivity