Download PDF
Synlett 2000; 2000(5): 0674-0676
DOI: 10.1055/s-2000-6628
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Copper Promoted Aryl/Saturated Heterocyclic C-N Bond Cross-Coupling with Arylboronic Acid and Arylstannane

Patrick Y. S. Lam* , Charles G. Clark, Simon Saubern, Jessica Adams, Kristin M. Averill, Dominic M. T. Chan, Andrew Combs
  • *DuPont Pharmaceuticals Company, Experimental Station, P.O. Box 80500, Wilmington, Delaware 19880-0500, USA; Fax (302) 695-9673; E-mail: patrick.y.lam@dupontpharma.com
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Arylboronic acid/cupric acetate arylation of N-H containing saturated heterocycles has been explored and found to give good yields of the cross-coupled products. Phenyltrimethylstannane is also found to arylate N-H containing heterocycles.

N-arylation - copper(II) acetate - stannane - boronic acid - cross-coupling