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Synlett 2000; 2000(10): 1476-1478
DOI: 10.1055/s-2000-7633
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A Mild and Efficient Dethioacetalization Employing FeCl3 · 6H2O: Synthesis of DNA-binding Pyrrolo[2,1-c][1,4]benzodiazepine Ring System and its Dimers

Ahmed Kamal* , E. Laxman, P. S. M. M. Reddy
  • *Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India; Fax 040-717 37 57; E-mail: ahmedkamal@iict.ap.nic.in
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Publication Date:
31 December 2000 (online)

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A simple and efficient dethioacetalization has been carried out by employing FeCl3 · 6H2O under mild conditions. This method has been investigated for the synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine antitumour antibiotics via deprotective cyclization process.

dethioacetalization - deprotective cyclization - ferric chloride hexahydrate - pyrrolobenzodiazepines - DC-81 dimers