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Synlett 2000; 2000(10): 1411-1414
DOI: 10.1055/s-2000-7635
DOI: 10.1055/s-2000-7635
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Solid-Phase Synthesis of Bis(guanidines) Based on an Aza Wittig/Carbodiimide-Mediated Annulation Process
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Publication History
Publication Date:
31 December 2000 (online)
An efficient solid-phase synthetic method towards bis(guanidines) is reported via aza Wittig coupling of a solid-supported bis(iminophosphorane) with an aromatic isothiocyanate to generate the corresponding solid-supported iminophosphorane, which upon exposure to a second aromatic isothiocyanate underwent aza Wittig/intramolecular cyclization and simultaneous cleavage to give the desired bis(guanidines).
bis(guanidines) - iminophosphoranes - solid-phase synthesis - combinatorial chemistry - aza Wittig reaction