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Horm Metab Res 2001; 33(2): 101-105
DOI: 10.1055/s-2001-12400
Original Clinical

© Georg Thieme Verlag Stuttgart · New York

Impaired Glucose Tolerance Without Hypertriglyceridemia Does not Enhance Postprandial Lipemia

K. Higashi1 , H. Shige1 , T. Ito1 , K. Nakajima1 , T. Ishikawa2 , H. Nakamura3 , F. Ohsuzu1
  • 1 First Department of Internal Medicine, National Defense Medical College
  • 2 SONY Wellness Center, SONY Cooperation
  • 3 Mitsukoshi Health and Welfare Foundation
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Publication History

Publication Date:
31 December 2001 (online)

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Postprandial lipemia has been thought to be one of risk factors for coronary heart disease, and enhances in potential patients for atherosclerotic disease. Patients with impaired glucose tolerance (IGT) often show hypertriglyceride, which is caused by enhanced portprandial lipemia. Therefore, postprandial lipemia in patients with IGT and without hypertriglyceridemia has not been cleared. We have examined the levels of plasma triglyceride and chylomicron remnants after a high fat meal load (1 250 kcal, 40 % fat and 420 mg cholesterol) in 13 normotriglyceridemic subjects with IGT and 10 controls with normal glucose tolerance (NGT). Chylomicron remnants were evaluated as remnant-like particles (RLP) that were not bound to an immunoaffinity gel mixture containing apo A-I and apo B-100 monoclonal antibody. RLP cholesterol levels 4 hours after the fat load were significantly lower in IGT subjects than in NGT subjects. Increase of RLP cholesterol after the fat meal load only significantly correlated with increase of insulin during the first 30 min after a 75 g oral glucose tolerance test, but not fasting lipid, insulinogenic index and HOMA-R (homeostasis model) in all subjects. These results suggest that postprandial response does not enhance in IGT subjects, and may associate with early-phase insulin secretion and without insulin resistance in normotriglyceridemic men with IGT or NGT.

Key words:

Chylomicron Remnants - Remnant-Like Particles (RLP) - Oral Fat Load - Insulin - Oral Glucose Tolerance Test

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K. Higashi, M.D.

First Department of Internal Medicine
National Defense Medical College

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