Einflussfaktoren auf die Anastomosenheilung

G. Meyer; R. A. Lang; F. W. Schildberg

doi:10.1055/s-2001-12711

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000091.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Viszeralchirurgie 2001; 36(2): 49-68
DOI: 10.1055/s-2001-12711

AKTUELLE CHIRURGIE

Einflussfaktoren auf die Anastomosenheilung

Factors that Influence Anastomis HealingG. Meyer, R. A. Lang, F. W. Schildberg

Chirurgische Klinik und Poliklinik im Klinikum Großhadern der Ludwig-Maximilians-Universität München

Further Information

Publication History

Publication Date:
18 May 2004 (online)

Abstract
Full Text
References

Permissions and Reprints

Zusammenfassung.

Die Anastomosenheilung kann in ihrem regelhaften Verlauf von einer Vielzahl unterschiedlicher Faktoren beeinflusst werden. Dabei ist von übergeordneter Bedeutung die Herstellung einer primär gas- und luftdichten, spannungslosen und gut durchbluteten Naht. Der Operateur und seine individuelle Operationstechnik insgesamt, aber weniger die gewählte Anastomosierungstechnik an sich spielt somit eine entscheidende Rolle. Daneben kann das Heilungsergebnis durch eine Reihe weiterer lokaler und allgemeiner Faktoren beeinflusst werden, deren praktische Relevanz für die Klinik allerdings im Einzelnen nur zum Teil gesichert ist. Dennoch ist ihre Kenntnis und Beachtung wegen der durch den Faktorensynergismus bestimmte Einflussnahme auf das Heilungsergebnis wichtig. Der Wunsch nach einer medikamentösen Heilungsmodulation käme vor allem Risikoanastomosen zugute, konnte aber bislang nur partiell erfüllt werden.

Factors that Influence Anastomis Healing.

Normal anastomotic healing can be influenced by numerous different factors. Achieving a primary gas tight, tension free and well perfused suture is of major importance. This is why the surgeon and his own surgical technique rather than the chosen technique of anastomosis play the leading role in anastomotic healing. In addition to this, the healing result may be influenced by a number of other local or general factors. The clinical relevance of most of these factors, however, has not been proven in prospective studies. Nonetheless, it appears to be most important to know and obey these factors, since they do influence the healing result. The goal of drug assisted anastomotic healing is of special healing for anastomoses in risk patients. This goal, however, has only been reached partially until today.

Schlüsselwörter:

Anastomosen - Anastomosenheilung - Anastomosentechnik - Einflussfaktoren - Gastrointestinaltrakt

Key words:

Anastomoses - anastomotic healing - influencing factors - technique of anastomoses - gastro intestinal tract

Literaturverzeichnis

1 Langer S, Kupczyk D. Entstehung der Nahtinsuffizienz. Langenbecks Arch Chir (Kongreßbericht 1982):. 1982; 358 253-258

PubMed Search in Google Scholar
2 Meyer G, Lang R A. Anastomosenheilung. Viszeralchirurgie. 2000; 35 153-165

Thieme Connect PubMed Search in Google Scholar
3 Jacobs G, Ulrich B. Klammernahtgeräte am Magen und Dünndarm. Langenbecks Arch Chir. 1981; 355 465-469

PubMed Search in Google Scholar
4 Bell C M, Lewis C B. Effect of neostigmine on integrity of iliorectal anastomoses. Br Med J. 1968; 3 587-588

PubMed Search in Google Scholar
5 Brolin R E, Ravitch M M. Studies in intestinal healing VI. Effect of pharmacologically induced peristalsis on fresh intestinal anastomoses in dogs. Arch Surg. 1980; 115 339-343

PubMed Search in Google Scholar
6 Scheele J. Grundlagen der Anastomosenheilung. In: Scheele J (Hrsg) Fibrinklebung. Springer Berlin Heidelberg New York Tokyo; 1984: S 115-119

Search in Google Scholar
7 Ballantyne G H. Intestinal suturing - review of the experimental foundations for traditional doctrines. Dis Colon Rectum. 1983; 26 836-843

PubMed Search in Google Scholar
8 Jiborn H, Ahonen J, Zederfeldt B. Healing of experimental colonic anastomoses. IV. Effect of suture technique on collagen metabolism in the colonic wall. Am J Surg. 1980; 139 406-413

Crossref PubMed Search in Google Scholar
9 Zederfeldt B, Jiborn H, Blomquist P. Effects of different suture techniques on healing of experimental colonic anastomoses. In: Thiede A, Hamelmann H (Hrsg) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer Berlin Heidelberg New York; 1982: S. 110-121

Search in Google Scholar
10 Arbogast R, Gay B, Höcht B. Der Einfluß des Nahtmaterials auf die mechanische Belastbarkeit von Darmanastomosen. Chirurg. 1978; 49 640-644

PubMed Search in Google Scholar
11 Debus E S, Lünstedt B, Geiger D, Schultz U, Thiede A. Handnaht, Klammernaht und Kompressionsanastomose - eine kontrollierte, vergleichende Untersuchung von 3 Anastomosenverfahren am Kolon des Schweines. In: Thiede A, Lünstedt B (Hrsg) Standards in der Viszerosynthese. Springer Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest; 1994: S. 24-31

Search in Google Scholar
12 Czerny V. Zur Darmresektion. Berl klin Wschr. 1880; 17 637-642-683-684

PubMed Search in Google Scholar
13 Halsted W S. Circular suture of the intestine - an experimental study. Am J Med Sci. 1887; 94 436-461

PubMed Search in Google Scholar
14 Buchin R, van Geertruyden J. Valeur comparée des sutures intestinales en un plan et en deux plans. Etude expérimentale et clinique. Acta Chir Belg. 1960; 59 461-480

PubMed Search in Google Scholar
15 Chung R S. Gastrointestinal anastomoses constructed with singly placed staples. Am J Surg. 1980; 139 876-879

Crossref PubMed Search in Google Scholar
16 Ellison G W. Wound healing in the gastrointestinal tract. Semin Vet Med Surg. 1989; 4 287-293

PubMed Search in Google Scholar
17 Graffner H, Andersson L, Löwenhielm P, Walther B. The healing process of anastomoses of the colon. A comparative study using single, double-layer or stapled anastomosis. Dis Colon Rectum. 1984; 27 767-771

Crossref PubMed Search in Google Scholar
18 Letwin E, Williams H YG. Healing of intestinal anastomosis. Can J Surg. 1967; 10 109-116

PubMed Search in Google Scholar
19 McAdams A J, Meikle G, Medina R. An experimental comparison of inversion and eversion colonic anastomoses. Dis Colon Rectum. 1969; 12 1-6

PubMed Search in Google Scholar
20 Yesilkaya Y, Soyhan N, Bengisu N, Sen M, Aritas Y. The effects of different suture techniques on collagen metabolism in experimental distal colonic anastomoses. Br J Surg. 1985; 72 987-989

PubMed Search in Google Scholar
21 Hamilton J E. Reappraisal of open intestinal anastomoses. Ann Surg. 1967; 165 917-924

PubMed Search in Google Scholar
22 Müller G, Kieninger G, Breucha G, Bustamante I, Neugebauer W. Vergleichende Untersuchungen ein- und zweireihiger Anastomosen am Schweinedünndarm. Langenbecks Arch Chir. 1978; 346 37-45

PubMed Search in Google Scholar
23 Nakanishi H. Experimental gut anastomoses and their revascularization. Aust NZ J Surg. 1975; 45 309-314

PubMed Search in Google Scholar
24 Jansen A, Becker A E, Brummelkamp W H, Keeman J N, Klopper P J. The importance of the apposition of the submucosal intestinal layers for primary wound healing of intestinal anastomosis. Surg Gynecol Obstet. 1981; 152 51-58

PubMed Search in Google Scholar
25 Ravitch M M. Observations on the healing of wounds of the intestines. Surgery. 1975; 77 665-673

PubMed Search in Google Scholar
26 Herrmann J B, Woodward S C, Pulaski E J. Healing of colonic anastomoses in the rat. Surg Gynecol Obstet. 1964; 119 269-275

PubMed Search in Google Scholar
27 Orr N WM. A single-layer intestinal anastomosis. Br J Surg. 1969; 56 771-774

PubMed Search in Google Scholar
28 Irvin T T, Edwards J P. Comparison of single-layer inverting, two-layer inverting, and everting anastomoses in the rabbit colon. Br J Surg. 1973; 60 453-457

PubMed Search in Google Scholar
29 Stoloff D, Snider III T G, Crawford M P, Taylor H W, Cox H U. End-to-end colonic anastomosis. A comparison of techniques in normal dogs. Vet Surg. 1984; 13 76-82

PubMed Search in Google Scholar
30 Högström H, Haglund U, Zederfeldt B. Suture technique and early breaking strength of intestinal anastomoses and laparotomy wounds. Acta Chir Scand. 1985; 151 441-443

PubMed Search in Google Scholar
31 Bronwell A W, Rutledge R, Dalton Jr M L. Single-layer open gastrointestinal anastomosis. Ann Surg. 1967; 165 925-932

PubMed Search in Google Scholar
32 Goligher J C. Visceral and parietal suture in abdominal surgery. Am J Surg. 1976; 131 130-140

Crossref PubMed Search in Google Scholar
33 Goligher J C, Lee PWG; Simpkins K C, Lintott D J. A controlled comparison of one- and two-layer techniques of suture for high and low colorectal anastomoses. Br J Surg. 1977; 64 609-614

PubMed Search in Google Scholar
34 Heifetz C J. Technique of single-layer end-to-end intestinal anastomosis by triangulation. Surg Clin N Am. 1966; 46 223-228

PubMed Search in Google Scholar
35 Irvin T T, Goligher J C, Johnston D. A randomized prospective clinical trial of single-layer and two-layer inverting intestinal anastomoses. Br J Surg. 1973; 60 457-460

PubMed Search in Google Scholar
36 Jiborn H, Ahonen J, Zederfeldt B. Healing of experimental colonic anastomoses. II. Breaking strength of the colon after left colon resection and anastomosis. Am J Surg. 1978; 136 595-599

Crossref PubMed Search in Google Scholar
37 Olinger A, Hildebrandt U, Pistorius G, Lindemann W, Menger M D. Laparoskopische 2-Etagenfusion der lumbalen Wirbelsäule mit Bagby-and-Kuslich (BAK)-Implantaten. Chirurg. 1996; 67 348-350

PubMed Search in Google Scholar
38 Raab M, Günther M, Godehardt E, Junginger T h. Tierexperimentelle Untersuchungen zum Nahtmaterial und zur Nahttechnik am Magen. Langenbecks Arch Chir. 1985; 365 267-277

PubMed Search in Google Scholar
39 McAdams A J, Meikle A G, Taylor J O. One layer or two layer colonic anastomoses?. Am J Surg. 1970; 120 546-550

PubMed Search in Google Scholar
40 Everett W G. A comparison of one layer and two layer techniques for colorectal anastomosis. Br J Surg. 1975; 62 135-140

PubMed Search in Google Scholar
41 Reichel K, Nagel R. Erfahrungen und Komplikationen bei der zwei- und einreihigen Enteroanastomose. Langenbecks Arch klin Chir. 1969; 323 362-373

Crossref PubMed Search in Google Scholar
42 Langer S, Pesendorfer H, Breining H, Cen M. Klinische und tierexperimentelle Studien zur Anastomosentechnik in der Darmchirurgie. Langenbecks Arch Chir. 1974; 335 309-320

PubMed Search in Google Scholar
43 Gill W, Fraser J, Carter D C, Hill R. Everted intestinal anastomosis. Surg Gynecol Obstet. 1969; 128 1297-1303

PubMed Search in Google Scholar
44 Hell K. 100 konsekutive Kolonresektionen mittels modifizierter einreihiger Naht. Helv Chir Acta. 1981; 48 833-837

PubMed Search in Google Scholar
45 Matheson N A, Irving A D. Single layer anastomosis after rectosigmoid resection. Br J Surg. 1975; 62 239-242

PubMed Search in Google Scholar
46 Peters Jr H E, Stanten A. Aseptic single layer anastomosis of the bowel. A review of one hundred seventy-five cases. Am J Surg. 1971; 122 159-163

Crossref PubMed Search in Google Scholar
47 Bennett R R, Zydeck F A. A comparison of single layer suture patterns for intestinal anastomosis. J Am Vet Med Assoc. 1970; 157 2075-2080

PubMed Search in Google Scholar
48 Jiborn H, Ahonen J, Zederfeldt B. Healing of experimental colonic anastomoses: the effect of suture technic on collagen concentration in the colonic wall. Am J Surg. 1978; 135 333-340

Crossref PubMed Search in Google Scholar
49 Jonsson T h, Högström H, Zederfeldt B. Effect of interrupted and continuous suturing on intestinal wound margin strength in rats. Eur Surg Res. 1993; 25 169-173

PubMed Search in Google Scholar
50 Olsen G B, Letwin E, Williams H TG. Clinical experience with the use of a single-layer intestinal anastomosis. Can J Surg. 1968; 11 97-100

PubMed Search in Google Scholar
51 John S, Fleischer F, Häring R. The enteroanastomosis: a micro-angiographic study of anastomotic healing. Chir Gastroent. 1976; 10 165-173

PubMed Search in Google Scholar
52 Shandall A, Lowndes R, Young H L. Colonic anastomotic healing and oxygen tension. Br J Surg. 1985; 72 606-609

PubMed Search in Google Scholar
53 Jiborn H, Ahonen J, Lindell B, Zederfeldt B. Cardiac output distribution after left colonic anastomosis in the rat. Eur Surg Res. 1979; 11 134-144

PubMed Search in Google Scholar
54 Schäfer K, Göller M, Stanka P, Ernst R, Zumtobel V. Revaskularisation von Kolonanastomosen. Langenbecks Arch Chir. 1991; 376 163-171

PubMed Search in Google Scholar
55 Bailey H R, La Voo J W, Max E, Smith K W, Butts D R, Hampton J M. Single-layer polypropylene colorectal anastomosis. Experience with 100 cases. Dis Colon Rectum. 1984; 27 19-23

PubMed Search in Google Scholar
56 Harder F, Kull C h. Fortlaufende einreihige Darmanastomose. Chirurg. 1987; 58 269-273

PubMed Search in Google Scholar
57 Vogelbach P, Harder F. Die Technik der Dickdarmanastomosen - die fortlaufende einreihige Kolonanastomose. In: Thiede A, Lünstedt B (Hrsg.) Standards in der Viszerosynthese. Springer Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest; 1994: S. 39-45

Search in Google Scholar
58 Wayand W, Rieger R, Umlauft M. Ein- oder zweireihig? Eine kontrollierte prospektive Studie zum Vergleich zweier Nahttechniken bei gastrointestinalen Anastomosen. Chirurg. 1984; 55 650-652

PubMed Search in Google Scholar
59 Zoedler T h, Becker H, Röher H D. Die fortlaufende einreihige Anastomose als Standardverfahren im Gastrointestinaltrakt. Chirurg. 1995; 66 50-53

PubMed Search in Google Scholar
60 Ellison G W, Jokinen M P, Park R D. End-to-end approximating intestinal anastomosis in the dog: a comparative fluorescein dye, angiographic and histopathologic evaluation. J Am Anim Hosp Assoc. 1982; 18 729-736

PubMed Search in Google Scholar
61 Houdart R, Lavergne A, Galian A, Hautefeuille P. Evolution anatomo-pathologique des anastomoses digestives bord à bord en un plan. Etude de 210 anastomoses coliques chez le rat du 2e au 180e jour. Gastroenterol Clin Biol. 1983; 7 465-473

PubMed Search in Google Scholar
62 Houdart R, Lavergne A, Valleur P, Villet R, Hautefeuille P. Vascular evolution of single-layer end-on colonic anastomosis. Dis Colon Rectum. 1985; 28 475-480

PubMed Search in Google Scholar
63 Jansen A, Becker A E, Brummelkamp W H, Keeman J N, Klopper P J. The importance of the apposition of the submucosal intestinal layers for primary wound healing of intestinal anastomosis. Surg Gynecol Obstet. 1981; 152 51-58

PubMed Search in Google Scholar
64 Lamesch A, Dociu N. Die mikrochirurgische Darmnaht: Untersuchungen am Rattendarm. Z Kinderchir. 1977; 21 263-274

PubMed Search in Google Scholar
65 Schäfer K, Loeweneck H, Stanka H, Ernst R, Zumtobel V. Mikrozirkulationsstörungen bei Colonanastomosen und ihre Bedeutung für die Pathogenese der Nahtinsuffizienz. Langenbecks Arch Chir. 1990; 375 24-32

PubMed Search in Google Scholar
66 Carter D C, Jenkins D HR, Whitfield H N. Omental reinforcement of intestinal anastomoses. An experimental study in the rabbit. Br J Surg. 1972; 59 129-133

Crossref PubMed Search in Google Scholar
67 Getzen L C, Roe R D, Holloway C K. Comparative study of intestinal anastomotic healing in inverted and everted closures. Surg Gynecol Obstet. 1966; 123 1219-1227

PubMed Search in Google Scholar
68 Herzog B. Die Darmnaht. Eine tierexperimentelle Studie und Erfahrungen mit einer eigenen Nahttechnik. Aktuelle Probleme in der Chirurgie. Bd. 20 Huber Bern Stuttgart Wien; 1974

Search in Google Scholar
69 Ravitch M M, Canalis F, Weinshelbaum A, McCormick J. Studies in intestinal healing: III. Observations on everting intestinal anastomoses. Ann Surg. 1967; 166 670-680

PubMed Search in Google Scholar
70 Polglase A L, Hughes E SR, McDermott F T, Burke F R. A comparison of end-to-end staple and suture colorectal anastomosis in the dog. Surg Gynecol Obstet. 1981; 152 792-796

PubMed Search in Google Scholar
71 Chowcat N L, Savage F J, Hembry R M, Boulos P B. Role of collagenase in colonic anastomoses: a reappraisal. Br J Surg. 1988; 75 330-334

PubMed Search in Google Scholar
72 Healey Jr J E, Mc Bride C M, Gallager H S. Is serosa-to-serosa approximation necessary in intestinal anastomosis?. Surg Forum. 1964; 15 297-299

PubMed Search in Google Scholar
73 Hertzler J H, Tuttle W M. Experimental method for an everting end-to-end anastomosis in the gastrointestinal tract. Arch Surg. 1952; 65 398-405

PubMed Search in Google Scholar
74 Hell K, Allgöwer M. Die Colonresektionen. Springer Berlin Heidelberg New York; 1976

Search in Google Scholar
75 Waninger J, Kauffmann G, Schmidt J, Gorenflo M. Mikroangiographische Befunde experimenteller Darmanastomosen. Fortschr Röntgenstr. 198; 7147 87-91

PubMed Search in Google Scholar
76 Wilker D, Sklarek J, Waldner H, Posel P. Nahtfreie Anastomosen an der Ratte, am Kaninchen und am Schwein. Langenbecks Arch Chir. 1988; 373 91-96

PubMed Search in Google Scholar
77 Ravitch M M, Ong T H, Gazzola L. A new, precise, and rapid technique of intestinal resection and anastomosis with staples. Surg Gynecol Obstet. 1974; 139 6-10

PubMed Search in Google Scholar
78 Hansen H, Sommer H J, Eichelkraut W. Die Durchblutung handgenähter und geklammerter Colonanastomosen. Langenbecks Arch Chir. 1987; 370 141-151

PubMed Search in Google Scholar
79 Karppinen V, Myllärniemi H. The vascular supply of healing wound. Acta Path Microbiol Scand. 1967; 71 59-67

PubMed Search in Google Scholar
80 Abramowitz H B, McAlister W H. A comparative study of small-bowel anastomoses by angiography and microangiography. Surgery. 1969; 66 564-569

PubMed Search in Google Scholar
81 Amosov N M, Berezovsky K K. Pulmonary resection with mechanical suture. J Thorac Cardiovasc Surg. 1961; 41 325-335

PubMed Search in Google Scholar
82 Ballantyne G H, Burke J B, Rogers G, Lampert E G, Boccia J. Accelerated wound healing with stapled enteric suture lines. Ann Surg. 1985; 201 360-364

Crossref PubMed Search in Google Scholar
83 Gritsman J J. Mechanical suture by soviet appartus in gastric resection: use in 4000 operations. Surgery. 1966; 59 663-669

PubMed Search in Google Scholar
84 Ravitch M M, Rivarola A, Grov J V. Rapid creation of gastric pouches with the use of an automatic stapling instrument?. J Surg Res. 1966; 6 64-65

PubMed Search in Google Scholar
85 Schumpelick V, Braun J. Rektumresektion mit coloanaler Anastomose. Ergebnisse der Kontinenz und Radikalität. Chirurg. 1991; 62 25-31

PubMed Search in Google Scholar
86 Smith D E, Karish A F, Chapman J P, Takaro T. Healing of the bronchial stump after pulmonary resection. J Thorac Cardiovasc Surg. 1963; 46 548-556

PubMed Search in Google Scholar
87 Greenstein A, Rogers P, Moss G. Doubled fourth-day colorectal anastomotic strength with complete retention of intestinal mature wound collagen and accelerated deposition following immediate full enteral nutrition. Surg Forum. 1978; 29 78-81

PubMed Search in Google Scholar
88 Scott R N, Farac R P, Goodman D G, Militano T C, Geelhoed G W, Chretlem P B. The role of inflammation in bronchial stump healing. Ann Surg. 1975; 181 381-385

PubMed Search in Google Scholar
89 Ballantyne G H. The experimental basis of intestinal suturing. Effect of surgical technique, inflammation, and infection on enteric wound healing. Dis Colon Rectum. 1984; 27 61-71

PubMed Search in Google Scholar
90 Sacks C L. Mechanical aspects of hemostasis with surgical stapling instruments. Ann NY Acad Sci. 1964; 115 414-417

PubMed Search in Google Scholar
91 Hess J L, Mc Curnin D M, Riley M G, Koehler K J. Pilot study for comparison of chromic catgut suture and mechanically applied staples in enteroanastomosis. J Am Anim Hosp Assoc. 1981; 17 409-414

PubMed Search in Google Scholar
92 Chapuis P H, Pheils M T, Dunn D, Bokey E L, Newland R C, Colquhoun K. Mortality, morbidity and survival after colectomy for colon cancer. Aust N Z J Surg. 1983; 53 223-228

PubMed Search in Google Scholar
93 Cohn I, Nance F C. Intestinal antisepsis and peritonitis from perforation. In: Sabiston DC (ed.) Textbook of Surgery. 12th Ed Saunders Philadelphia; 1981: pp. 1073-1076

Search in Google Scholar
94 Steichen F M. Entwicklung der Maschinennaht und Vergleich mit der manuellen Naht in der Chirurgie. Langenbecks Arch Chir. 1987; 372 79-84

PubMed Search in Google Scholar
95 Beart jr R W, Kelly K A. Randomized prospective evaluation of the EEA stapler for colorectal anastomoses. Am J Surg. 1981; 141 43-147

PubMed Search in Google Scholar
96 Dziki A J, Duncan M D, Harmon J W, Saini M, Malthaner R A, Trad K S, Fernicola M T, Hakki F, Ugarte R M. Advantages of handsewn over stapled bowel anastomosis. Dis Colon Rectum. 1991; 34 442-448

PubMed Search in Google Scholar
97 Penninckx F M, Kerremans R P, Geboes K J. The healing of single- and double-row stapled circular anastomoses. Dis Colon Rectum. 1984; 27 714-719

PubMed Search in Google Scholar
98 Scheele J, Groitl H, Pesch H -J. Auto-Suture oder Handnaht? Tierexperimentelle Untersuchungen zum Einfluß der Anastomosentechnik auf die Wundheilung am Verdauungstrakt am Beispiel des Hundekolons. Coloproctology. 1984; 6 65-76

PubMed Search in Google Scholar
99 Kozol R A, Mulligan M, Downes R J, Forouhar F A, Kreutzer D L. Early colonic anastomotic edema. Evaluation of stapled vs hand-sewn anastomoses. Dis Colon Rectum. 1988; 31 503-506

PubMed Search in Google Scholar
100 Templeton J L, McKelvey S TD. Low colorectal anastomoses. An experimental assessment of two sutured and two stapled techniques. Dis Colon Rectum. 1985; 28 38-41

PubMed Search in Google Scholar
101 Bubrick M P, Lundeen J W, Hitchcock C R. A comparative radiographic study of low anterior colon anastomoses in dogs. Surgery. 1981; 89 454-459

PubMed Search in Google Scholar
102 Dunn D H, Robbins P, Decanini C, Goldberg S, Delaney J P. A comparison of stapled and hand-sewn colonic anastomoses. Dis Colon Rectum. 1978; 21 636-639

PubMed Search in Google Scholar
103 Koruda M J, Rollandelli R H. Experimental studies on healing of colonic anastomoses. J Surg Res. 1990; 48 504-515

Crossref PubMed Search in Google Scholar
104 Berman S, Hashizume M, Yang Y, DuPree J, Matsumoto T. Intraoperative hemostasis and wound healing in intestinal anastomoses using the ILA stapling device. Am J Surg. 1988; 155 520-525

PubMed Search in Google Scholar
105 Lünstedt B, Debus S, Thiede A. Anastomosenheilung bei verschiedenen Nahtverfahren im Gastrointestinaltrakt. Physiologie, experimentelle und klinische Ergebnisse. Zentralbl Chir. 1993; 118 1-7

PubMed Search in Google Scholar
106 Smith C R, Cokelet G R, Adams J T, Schwartz S I. Vascularity of gastrointestinal staple lines demonstrated with silicone rubber injection. Am J Surg. 1981; 142 563-566

Crossref PubMed Search in Google Scholar
107 Tuchmann A, Dinstl K, Strasser K, Armbruster C. Stapling devices in gastrointestinal surgery. Int Surg. 1985; 70 23-27

PubMed Search in Google Scholar
108 Wheeless jr C R, Smith J J. A comparison of the flow of jodine 125 through three different intestinal anastomoses: standard, gambee, and stapler. Obstet Gynecol. 1983; 62 513-518

PubMed Search in Google Scholar
109 Shikata J, Shida T. Experimental studies by the resin-casting method on the vascular structure of the colon following stapler anastomoses. Dis Colon Rectum. 1985; 28 341-346

PubMed Search in Google Scholar
110 Allendorf J DF, Bessler M, Kayton M L, Whelan R L, Treat M R, Nowygrod R. Tumor growth after laparotomy or laparoscopy. A preliminary study. Surg Enodosc. 1995; 9 49-52

PubMed Search in Google Scholar
111 Allgöwer M, Hasse J, Herzog B. Colonresektionen. Chirurg. 1971; 42 1-10

PubMed Search in Google Scholar
112 Böttger G. Verhütung und Behandlung von Komplikationen in der Colonchirurgie. Chirurg. 1971; 42 10-16

PubMed Search in Google Scholar
113 Deucher F, Blessing H. Resultate der abdominalen und transanalen sphinctererhaltenden Eingriffe beim Rektosigmoidkarzinom. Schweiz Med Wschr. 1973; 103 769-775

PubMed Search in Google Scholar
114 Jiborn H, Ahonen J, Zederfeldt B. Healing of experimental colonic anastomoses. I. Bursting strength of the colon after left colon resection and anastomosis. Am J Surg. 1978; 136 587-594

Crossref PubMed Search in Google Scholar
115 Bary S. von .Klinische und experimentelle Untersuchungen zur Wundheilung des Dickdarmes unter besonderer Berücksichtigung der gewebeständigen Fibrinolyse und Kollagenolyse. Habilitationsschrift Ludwig-Maximilians-Universität München; 1979

Search in Google Scholar
116 Chlumsky V. Experimentelle Untersuchungen über die verschiedenen Methoden der Darmvereinigung. Bruns Beitr Klin Chir. 1899; 25 539-600

PubMed Search in Google Scholar
117 Waninger J, Kauffmann G W, Shah I A, Farthmann E H. Influence of the distance between interrupted sutures and the tension of sutures on the healing of experimental colonic anastomoses. Am J Surg. 1992; 163 319-323

Crossref PubMed Search in Google Scholar
118 Ehrlich H P. Regulation der Wundheilung aus der Sicht des Bindegewebes. Chirurg. 1995; 66 165-173

PubMed Search in Google Scholar
119 Jonsson T h, Högström H. Diathermy-induced inflammation does not affect suture holding capacity of intestinal anastomoses. Eur Surg Res. 1991; 23 235-239

PubMed Search in Google Scholar
120 Denecke H, Wirsching R. Colorectale Anastomosen. Chirurg. 1984; 55 638-644

PubMed Search in Google Scholar
121 Fielding L P, Stewart-Brown S, Blesovsky L, Kearney G. Anastomostic integrity after operations for large-bowel cancer: a multicentre study. Br Med J. 1980; 281 411-414

PubMed Search in Google Scholar
122 McArdle C S, Hole D. Impact of variability among surgeons on postoperative morbidity and mortality and ultimate survival. Br Med J. 1991; 302 1501-1505

PubMed Search in Google Scholar
123 Heughan C h, Grislis G, Hunt T K. The effect of anaemia on wound healing. Ann Surg. 1974; 179 163-167

PubMed Search in Google Scholar
124 Schrock T R, Deveney C W, Dunphy J E. Factors contributing to leakage of colonic anastomoses. Ann Surg. 1973; 177 513-518

PubMed Search in Google Scholar
125 Stelzner F. Operationstechnisch bedingte Mißerfolge bei der Behandlung des Kolon- und Rektumkarzinoms. Zentralbl Chir. 1977; 102 1559-1563

PubMed Search in Google Scholar
126 Lünstedt B, Debus S, Thiede A. Standards in der Viszerosynthese. Anastomosenheilung bei verschiedenen Nahtverfahren im Gastrointestinaltrakt - Physiologie, experimentelle und klinische Ergebnisse. In: Thiede A, Lünstedt B (Hrsg) Springer Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest; 1994: S. 3-13

Search in Google Scholar
127 Stephens F O, Hunt T K. Effect of changes in inspired oxygen and carbon dioxide tensions on wound tensile strength: an experimental study. Ann Surg. 1971; 173 515-519

Crossref PubMed Search in Google Scholar
128 Udenfriend S. Formation of hydroxyproline in collagen. Science. 1966; 152 1335-1340

PubMed Search in Google Scholar
129 Kivisaari J, Vihersaari T, Renvall S, Niinikoski J. Energy metabolism of experimental wounds at various oxygen environments. Ann Surg. 1975; 181 823-828

PubMed Search in Google Scholar
130 Silver I A. Local and systemic factors which affect the proliferation of fibroblasts. In: Kulonen E, Pikkarainen J (Eds.) Biology of Fibroblast. Academic Press London; 1973: pp. 507-519

Search in Google Scholar
131 McLachlin A D, Denton D W. Omental protection of intestinal anastomoses. Am J Surg. 1973; 125 134-140

Crossref PubMed Search in Google Scholar
132 Cartier R, Brunette I, Hashimoto K, Bourne W M, Schaff H V. Angiogenetic factor: a possible mechanism for neovascularization produced by omental pedicles. J Thorac Cardiovasc Surg. 1990; 99 264-268

PubMed Search in Google Scholar
133 Adams W, Ctercteko G, Bilous M. Effect of an omental wrap on the healing and vascularity of compromised intestinal anastomoses. Dis Colon Rectum. 1992; 35 731-738

Crossref PubMed Search in Google Scholar
134 Goldsmith H S. Protection of low rectal anastomosis with intact omentum. Surg Gynecol Obstet. 1977; 144 584-586

PubMed Search in Google Scholar
135 Lanter B, Mason R A. Use of omental pedicle graft to protect low anterior colonic anastomosis. Dis Colon Rectum. 1979; 22 448-451

PubMed Search in Google Scholar
136 Everett W G. Suture materials in general surgery. Progr Surg. 1970; 8 14-37

PubMed Search in Google Scholar
137 Howes E L, Sooy J W, Harvey S C. The healing of wounds as determined by their tensile strength. JAMA. 1929; 92 42-45

Crossref PubMed Search in Google Scholar
138 Khoury G A, Waxman B P. Large bowel anastomoses. I. The healing process and sutured anastomoses. A review. Br J Surg. 1983; 70 61-63

PubMed Search in Google Scholar
139 Kracht M, Hay J M, Fagniez P L, Fingerhut A. Ileocolonic anastomosis after right hemicolectomy for carcinoma: stapled or hand-sewn? A prospective, multicenter, randomized trial. Int J Colorectal Dis. 1993; 8 29-33

Crossref PubMed Search in Google Scholar
140 Nöthiger F, Ziegler W, Finger J, Kaufmann R. Nahtmaterial in der Darmanastomose. Helv Chir Acta. 1980; 14 1-42

PubMed Search in Google Scholar
141 Winkle jr van W, Hastings J C. Considerations in the choice of suture material for various tissues. Surg Gynecol Obstet. 1972; 135 113-126

PubMed Search in Google Scholar
142 Fontaine C J, Dudley H AF. Assessment of suture materials for intestinal use by an extramucosal inplant technique and a quantitative histological evaluation. Br J Surg. 1978; 65 288-290

PubMed Search in Google Scholar
143 Lord M G, Broughton A C, Williams H TG. A morphologic study on the effect of suturing the submucosa of the large intestine. Surg Gynecol Obstet. 1978; 146 211-216

PubMed Search in Google Scholar
144 Nockemann P F. Die chirurgische Naht. Thieme 3. Auflage Stuttgart New York; 1980

Search in Google Scholar
145 Edlich R F, Panek P H, Rodenheaver G T, Turnbull V G, Kurtz L D, Edgerton M T. Physical and chemical configuration of sutures in the development of surgical infection. Ann Surg. 1973; 177 679-688

PubMed Search in Google Scholar
146 Herrmann J B. Changes in the tensile strength and knot security of surgical sutures in vivo. Arch Surg. 1973; 106 707-710

PubMed Search in Google Scholar
147 Postlethwait R W. Long-term comparative study of nonabsorbable sutures. Ann Surg. 1970; 171 892-

PubMed Search in Google Scholar
148 Postlethwait R W. Polyglycolic acid surgical suture. Arch Surg. 1970; 101 489-494

PubMed Search in Google Scholar
149 Foster M E, Brennan S S, Morgan A, Leaper D J. Colonic ischaemia and anastomotic healing. Eur Surg Res. 1985; 17 133-139

PubMed Search in Google Scholar
150 Magilligan jr D J, De Weese J A. Knot security and synthetic suture materials. Am J Surg. 1974; 127 355-358

Crossref PubMed Search in Google Scholar
151 Trimpi H D, Khubchandani I T, Sheets J A, Stasik J J. Advances in intestinal anastomosis: Experimental study and an analysis of 984 patients. Dis Colon Rectum. 1977; 20 107-117

PubMed Search in Google Scholar
152 Hudemann H. Chirurgisches Nahtmaterial. Fischer Jena; 1959

Search in Google Scholar
153 Deveney K E, Way L W. Effect of different absorbable sutures on healing of gastrointestinal anastomoses. Am J Surg. 1977; 133 86-94

Crossref PubMed Search in Google Scholar
154 Durdey P, Bucknall T E. Assessment of sutures for use in colonic surgery: An experimental study. J R Soc Med. 1984; 77 472-477

PubMed Search in Google Scholar
155 Hastings J C, van Winkle W, Barker E, Hines D, Nichols W. Effect of suture materials on healing wounds of the stomach and the colon. Surg Gynecol Obstet. 1975; 140 701-707

PubMed Search in Google Scholar
156 Nöthiger F. Vergleichende Untersuchungen zur Wertigkeit des Nahtmaterials bei der Dickdarmanastomose. In: Thiede A, Hamelmann H (Hrsg) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer Berlin Heidelberg New York; 1982: S. 122-127

Search in Google Scholar
157 Riddick D H, De Grazia C T, Maenza R M. Comparison of polyglactic and polyglycolic acid sutures in reproductive tissue. Fertility and Sterility. 1977; 28 1220-1225

PubMed Search in Google Scholar
158 Lünstedt B, Thiede A. Polydioxanon (PDS) - ein neues monofiles, synthetisches, absorbierbares Nahtmaterial. Zugfestigkeitsuntersuchungen in einem klinisch kontrollierten Versuch am Dickdarm des Menschen und physikalische Parameter im in-vitro-Test. Chirurg. 1983; 54 103-107

PubMed Search in Google Scholar
159 Stephens F O, Hunt T K, Dunphy J E. Study of traditional methods of care on the tensile strength of skin wounds in rats. Am J Surg. 1971; 122 78-80

Crossref PubMed Search in Google Scholar
160 Farella S, Cola B; Franchini A. Endoskopische Beurteilung der verschiedenen Heilungsstadien kolorektaler Anastomosen. Colo-proctology. 1984; 2 86-90

PubMed Search in Google Scholar
161 Entner M, Heimberger H. One row anastomosis in colonic operations with antibiotic prophylaxis. Surg Gynecol Obstet. 1985; 161 136-138

PubMed Search in Google Scholar
162 Thiede A. Biologische Wertigkeit der Nahtmaterialien. In: Thiede A, Hamelmann H (Hrsg) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer Berlin Heidelberg New York; 1982: S.238-252

Search in Google Scholar
163 Letwin E R. Evaluation of polyglycolic acid sutures in colonic anastomoses. Can J Surg. 1975; 18 30-33

PubMed Search in Google Scholar
164 Kapadia C R, Mann J B, McGeehan D, Jose Biglin J E, Waxman B P, Dudley H AF. Behaviour of synthetic absorbable sutures with and without synergistic enteric infection. Eur Surg Res. 1983; 15 67-72

PubMed Search in Google Scholar
165 Cowley L L. Wire sutures: braided or monofilament?. Am J Surg. 1967; 113 472-474

Crossref PubMed Search in Google Scholar
166 Katz S, Izhar M, Mirelman D. Bacterial adherence to surgical sutures. A possible factor in the suture induced infection. Ann Surg. 1981; 194 35-41

Crossref PubMed Search in Google Scholar
167 Mc Geehan D, Hunt D, Chaudhuri A, Rutter P. An experimental study of the relationship between synergistic wound sepsis and suture materials. Br J Surg. 1980; 67 636-638

PubMed Search in Google Scholar
168 Blomstedt R, Österberg B. Fluid absorption and capillarity of suture materials. Acta Chir Scand. 1977; 143 67-70

PubMed Search in Google Scholar
169 Dudley H AF, Kapadia C R. Sutures and infection: studies of conventional materials and new synthetic absorbables. In: Thiede A, Hamelmann H (Hrsg) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer Berlin Heidelberg New York; 1982: S. 34-38

Search in Google Scholar
170 Eichfuss H P. Der Bauchchirurg und sein Nahtmaterial. Med Welt. 1976; 27 562-565

PubMed Search in Google Scholar
171 Schütze U, Henningsen B, Daum R, Seufert R. Polyglycolic acid sutures for intestinal anastomoses in paediatric surgery. Experimental and first clinical findings. Z Kinderchir. 1978; 25 76-80

PubMed Search in Google Scholar
172 Blomstedt B, Österberg B, Bergstrand A. Suture material and bacterial transport. An experimental study. Acta Chir Scand. 1977; 143 71-73

PubMed Search in Google Scholar
173 Thiede A, Jostarndt L, Lünstedt B, Sonntag H G. Kontrollierte experimentelle histologische und mikrobiologische Untersuchungen zur Hemmwirkung von Polyglycolsäurefäden bei Infektionen. Chirurg. 1980; 51 35-38

PubMed Search in Google Scholar
174 Thiede A, Jostarndt L, Lünstedt B, Sonntag H G. Zum Verhalten kontaminierter absorbierbarer Nahtmaterialien in vivo. In: Thiede A, Hamelmann H (Hrsg) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer Berlin Heidelberg New York; 1982: S 55-63

Search in Google Scholar
175 Arbogast R, Gay B, Höcht B. Der Einfluß des Nahtmaterials auf die mechanische Belastbarkeit von Darmanastomosen. Chirurg. 1978; 49 640-644

PubMed Search in Google Scholar
176 Kratzer G L. Intestinal anastomosis and abdominal wound closure using monofilament prolene polypropylene suture: report of fifty cases. Dis Colon Rectum 1978 21: 342-345

Search in Google Scholar
177 Munday C, McGinn F P. A comparison of polyglycolic acid and catgut sutures in rat colonic anastomoses. Br J Surg. 1976; 63 870-872

PubMed Search in Google Scholar
178 Hawley P R. Causes and prevention of colonic anastomotic breakdown. Dis Colon Rectum. 1973; 16 272-277

PubMed Search in Google Scholar
179 Hesp F LEM, Hendriks T, Lubbers E JC. de Boer HHM. Wound healing in the intestinal wall. A comparison between experimental ileal and colonic anastomoses. Dis Colon Rectum. 1984; 27 99-104

Crossref PubMed Search in Google Scholar
180 Irvin T T, Hunt T K. The effect of trauma on colonic healing. Br J Surg. 1974; 61 430-436

PubMed Search in Google Scholar
181 Le Veen H H, Wapnick S, Falk G, Olivas O, Bhat D, Gaurdre M, Patel M. Effects of prophylactic antibiotics on colonic healing. Am J Surg. 1976; 131 47-53

Crossref PubMed Search in Google Scholar
182 Schardey H M, Kamps T, Rau H G, Gatermann S, Baretton G, Schildberg F W. Bacteria: A major factor of anastomotic insufficiency following gastrectomy. Antimicrob Agents Chemother. 1994; 38 2564-2567

PubMed Search in Google Scholar
183 Cohn I. jr . Intestinal antisepsis. Surg Gynecol Obstet. 1970; 130 1006-1014

PubMed Search in Google Scholar
184 Högström H, Jiborn H, Zederfeldt B, Haglund U. Influence of intraperitoneal Escherichia coli with septicemia on the healing of colonic anastomoses and skin wounds. Eur Surg Res. 1985; 17 128-132

PubMed Search in Google Scholar
185 Lee J T, Ahrenholz D H, Nelson R D, Simmons R L. Mechanisms of the adjuvant effect of hemoglobin in experimental peritonitis. V. The significance of the coordinated iron component. Surgery. 1979; 86 41-48

PubMed Search in Google Scholar
186 Mellish R WP, Ty T C, Keller D J. A study of intestinal healing. J Pediatr Surg. 1968; 3 286-291

Crossref PubMed Search in Google Scholar
187 Canalis F, Ravitch M M. Study of healing of inverting and everting intestinal anastomoses. Surg Gynecol Obstet. 1968; 126 109-114

PubMed Search in Google Scholar
188 Rusca J A, Bornside G H, Cohn I. Everting versus inverting gastrointestinal anastomoses: bacterial leakage and anastomotic disruption. Ann Surg. 1969; 169 727-735

PubMed Search in Google Scholar
189 Abramowitz H B, Butcher H R. Everting and inverting intestinal anastomosis: an experimental study of comparative safety. Am J Surg. 1971; 121 52-53

Crossref PubMed Search in Google Scholar
190 Hawley P R, Faulk W P, Hunt T K, Dunphy J E. Collagenase activity in the gastro-intestinal tract. Br J Surg. 1970; 57 896-900

Crossref PubMed Search in Google Scholar
191 Hesp F LEM, Hendriks T, Lubbers E JC, De Boer H HM. Wound healing in the intestinal wall. Effects of infection on experimental ileal and colonic anastomoses. Dis Colon Rectum. 1984; 27 462-467

PubMed Search in Google Scholar
192 Irvin T T, Hunt T K. Pathogenesis and prevention of disruption of colonic anastomoses in traumatized rats. Br J Surg. 1974; 61 437-439

PubMed Search in Google Scholar
193 Irvin T T. Collagen metabolism in infected colonic anastomoses. Surg Gynecol Obstet. 1976; 143 220-224

PubMed Search in Google Scholar
194 Morgenstern L, Yamakawa T, Ben-Shoshan M, Lippman H. Anastomotic leakage after low colonic anastomosis. Clinical and experimental aspects. Am J Surg. 1972; 123 104-109

Crossref PubMed Search in Google Scholar
195 Yamakawa T, Patin C S, Sobel S, Morgenstern L. Healing of colonic anastomoses following resection for experimental „diverticulitis”. Arch Surg. 1971; 103 17-20

PubMed Search in Google Scholar
196 Högström H, Haglund U. Neutropenia prevents decrease in strength of rat intestinal anastomosis: Partial effect of oxygen free radical scavengers and allopurinol. Surgery. 1986; 99 716-720

PubMed Search in Google Scholar
197 Ohlsson K. Polymorphonuclear leukocyte collagenase. In: Woolley D, Evanson J (Eds.) Collagenase in normal and pathological connective tissue. Wiley Chichester; 1980: pp. 209-222

Search in Google Scholar
198 Shandall A A, Williams G T, Hallett M B, Young H L. Colonic healing: a role for polymorphonuclear leucocytes and oxygen radical production. Br J Surg. 1986; 73 225-228

PubMed Search in Google Scholar
199 Starkey P H. Elastase and cathepsin G. In: Barrett AJ (Ed.) The serine proteinases of human neutrophil leucocytes and spleen. Elsevier Amsterdam; 1977: pp. 57-89

Search in Google Scholar
200 Cronin K, Jackson D S, Dunphy J E. Changing bursting strength and collagen content of the healing colon. Surg Gynecol Obstet. 1968; 126 747-753

PubMed Search in Google Scholar
201 Jönsson K, Jiborn H, Zederfeldt B. Breaking strength of small intestinal anastomoses. Am J Surg. 1983; 145 800-803

Crossref PubMed Search in Google Scholar
202 Foster M E, Johnson C D, Billings P J, Davies P W, Leaper D J. Intraoperative antegrade lavage and anastomotic healing in acute colonic obstruction. Dis Colon Rectum. 1986; 29 255-259

PubMed Search in Google Scholar
203 Nagelschmidt M, Becker D, Stuttmann R, Engelhardt G H. Fibronektin-Mangel verzögert die Wundheilung bei Ratten. Langenbecks Arch (Chir Forum) 1986: 33-37

Search in Google Scholar
204 Nagelschmidt M, Becker D, Bönninghoff N, Engelhardt G H. The effect of fibronectin therapy and fibronectin deficiency on healing of rat burns and excision wounds. Res Exp Med. 1987; 187 217-223

Crossref PubMed Search in Google Scholar
205 Metzger Z, Hoffeld J T, Oppenheim J J. Suppression of fibroblast proliferation by activated macrophages: Involvement of H₂O₂ and a non-prostaglandin E product of the cyclooxygenase pathway. Cell Immunol. 1986; 100 501-514

Crossref PubMed Search in Google Scholar
206 Phan S M, McGarry B M, Loeffler K M, Kunkel S L. Regulation of macrophage-derived fibroblast growth factor release by arachidonate metabolites. J Leukoc Biol. 1987; 42 106-113

PubMed Search in Google Scholar
207 Sugarman B J, Aggarwal B B, Hass P E, Figari I S, Palladino jr M A, Shepard H M. Recombinant human tumor necrosis factor-α: Effects on proliferation of normal and transformed cells in vitro. Science. 1985; 230 943-945

PubMed Search in Google Scholar
208 Sugarman B J, Lewis G D, Eessalu T E, Aggarwal B B, Shepard H M. Effects of growth factors on the antiproliferative activity of tumor necrosis factors. Cancer Res. 1987; 47 780-786

PubMed Search in Google Scholar
209 Ahrendt G M, Gardner K, Barbul A. Loss of colonic structural collagen impairs healing during intra-abdominal sepsis. Arch Surg. 1994; 129 1179-1183

Crossref PubMed Search in Google Scholar
210 Högström H, Bondeson L, Haglund U. Neutrophil-induced decrease in wound margin strength after intestinal anastomosis: influence on collagen and mechanisms of granulocyte action. Eur Surg Res. 1988; 20 260-266

PubMed Search in Google Scholar
211 Jonsson T h, Högström H. Neutrophil-dependent decrease in early wound margin strength. Arch Surg. 1991; 126 1423-1426

PubMed Search in Google Scholar
212 Nahai F, Lamb J M, Havican R G, Stone H H. Factors involved in disruption of intestinal anastomoses. Am Surg. 1977; 43 45-51

PubMed Search in Google Scholar
213 Faß J. Die Wundheilungsstörung in der Chirurgie des colo-rectalen Carcinoms. Eine multifaktorielle Computeranalyse. Langenbecks Arch Chir. 1985; 367 63-73

PubMed Search in Google Scholar
214 Giercksky K E, Danielsen S, Garberg O, Gruener O P, Holter O, Johnson J A, Nygaard K, Ofstad E, Stadaas J, Viddal K O. A single dose tinidazole and doxycycline prophylaxis in elective surgery of colon and rectum. A prospective controlled clinical multicenter study. Ann Surg. 1982; 195 227-231

PubMed Search in Google Scholar
215 Görtz G, Häring R, Raetzel G, Rodloff A. Cephalosporine zur Infektionsprophylaxe im Rahmen der Kolonchirurgie. FAC Fortschritte d. antimikrobiellen und antineoplastischen Chemotherapie. 1982; 1 237-245

PubMed Search in Google Scholar
216 Hepp J, Käufer C. Infektionsverhütung in der Dickdarm-Chirurgie durch Cefoxitin und orthograde Darmspülung. Krankenhausarzt. 1982; 55 885-891

PubMed Search in Google Scholar
217 Hildebrandt J, Diettrich H. Moderne mechanisch-antibiotische Vorbereitung bei kolorektalen Operationen. Ergebnisse einer prospektiven Studie. Zentralbl Chir. 1985; 110 93-97

PubMed Search in Google Scholar
218 Jostarndt L, Thiede A, Sonntag H G, Hamelmann H. Die systemische Antibioticumprophylaxe in der elektiven Colonchirurgie. Ergebnisse einer kontrollierten Studie. Chirurg. 1981; 52 398-402

PubMed Search in Google Scholar
219 Kusche J, Stahlknecht C D. Antibiotikaprophylaxe bei colorectalen Operationen. Gibt es ein Mittel der Wahl?. Chirurg. 1981; 52 577-585

PubMed Search in Google Scholar
220 Lohr J, Wagner P K, Rothmund M. Perioperative Antibiotikaprophylaxe (Einmal- oder Mehrfachgabe) bei elektiven colorectalen Eingriffen. Chirurg. 1984; 55 512-514

PubMed Search in Google Scholar
221 Cohen S R, Cornell C N, Collins M H, Sell J E, Blanc W A, Altman R P. Healing of ischemic colonic anastomoses in the rat: role of antibiotic preparation. Surgery. 1985; 97 443-446

PubMed Search in Google Scholar
222 Schardey H M, Kamps T, Rau H G, Baretton G, Gatermann S, Exner H, Schildberg F W. Can oesophago-intestinal anastomotic leakage develop in the complete absence of bacteria? A comparison of normal and germ-free rats. Int J Surg Science. 1997; 4 9-13

PubMed Search in Google Scholar
223 Schardey H M, Joosten U, Finke U, Staubach K H, Schauer R, Heiss A, Kooistra A, Rau H G, Nibler R, Lüdeling S, Unertl K. Ruckdeschel G, Exner, H, Schildberg FW. The prevention of anastomotic leakage after total gastrectomy with local decontamination. Ann Surg. 1997; 225 172-180

Crossref PubMed Search in Google Scholar
224 Schardey H M, Krämling H J, Cramer C, Kusenack U, Hadersbeck J, Schildberg F W. Risikofaktoren und pathogene Mikroorganismen bei Patienten mit insuffizienter Ösophago-Jejunostomie nach Gastrektomie. Zentralblatt Chir. 1998; 123 46-52

PubMed Search in Google Scholar
225 Curley S A, Allison D C, Smith D E, Doberneck R C. Analysis of techniques and results in 347 consecutive colon anastomoses. Am J Surg. 1988; 155 597-601

PubMed Search in Google Scholar
226 Rolandelli R H, Koruda M J, Settle R G, Rombeau J L. The effect of enteral feedings supplemented with pectin on the healing of colonic anastomoses in the rat. Surgery. 1986; 99 703-707

PubMed Search in Google Scholar
227 Rolandelli R H, Koruda M J, Settle R G, Rombeau J L. Effects of intraluminal infusion of short-chain fatty acids on the healing of colonic anastomosis in the rat. Surgery. 1986; 100 198-204

PubMed Search in Google Scholar
228 Blomquist P, Jiborn H, Zederfeldt B. Effect of diverting colostomy on collagen metabolism in the colonic wall. Studies in the rat. Am J Surg. 1985; 149 330-333

PubMed Search in Google Scholar
229 Blomquist P, Jiborn H, Zederfeldt B. Effect of diverting colostomy on breaking strength of anastomoses after resection of the left side of the colon. Studies in the rat. Am J Surg. 1985; 149 712-715

PubMed Search in Google Scholar
230 Udén P, Blomquist P, Jiborn H, Zederfeldt B. Influence of proximal colostomy on the healing of a left colon anastomosis: an experimental study in the rat. Br J Surg. 1988; 75 325-329

PubMed Search in Google Scholar
231 Wara P, Sorensen K, Berg V. Proximal fecal diversion: review of ten years’ experience. Dis Colon Rectum. 1981; 24 114-119

PubMed Search in Google Scholar
232 Blomquist P, Ahonen J, Jiborn H, Zederfeldt B. The effect of relative bowel rest on healing of colonic anastomoses. Collagen synthesis and content in the colonic wall after left colon resection and anastomosis in the rat. Acta Chir Scand. 1984; 150 677-681

PubMed Search in Google Scholar
233 Blomquist P, Jiborn H, Zederfeldt B. The effect of relative bowel rest on healing of colonic anastomoses. Breaking strength and collagen in the colonic wall following left colon resection and anastomosis in the rat. Acta Chir Scand. 1984; 150 671-675

PubMed Search in Google Scholar
234 Högström H, Haglund U, Zederfeldt B. Beneficial effect of proteinase inhibitors on early breaking strength of intestinal anastomoses. Acta Chir Scand. 1985; 151 529-532

PubMed Search in Google Scholar
235 Young H L, Wheeler M H. Results of a prospective randomized doubleblind trial of aprotinin in colonic surgery. World J Surg. 1984; 8 367-373

Crossref PubMed Search in Google Scholar
236 Hawley P R, Page Faulk W. A circulatory collagenase inhibitor. Br J Surg. 1970; 57 900-904

PubMed Search in Google Scholar
237 Högström H, Haglund U. Postoperative decrease in suture holding capacity in laparotomy wounds and anastomoses. Acta Chir Scand. 1985; 151 533-535

PubMed Search in Google Scholar
238 Jönsson K, Jiborn H, Zederfeldt B. Collagen metabolism in small intestinal anastomosis. Am J Surg. 1987; 154 288-291

Crossref PubMed Search in Google Scholar
239 Bary S v on, Kortmann H, Köpcke W. Berstungsdrücke des enterotomierten Rattencolons unter Proteinaseinhibition. Res Exp Med. 1976; 168 123-128

Crossref PubMed Search in Google Scholar
240 Delaney P, Lalor D. Enzyme inhibition in colorectal surgery. Br J Surg. 1976; 63 23-24

PubMed Search in Google Scholar
241 Young H L, Wheeler M H. Collagenase inhibition in the healing colon. J R Soc Med. 1983; 76 32-36

PubMed Search in Google Scholar
242 Virca G D, Metz G, Schnebli H P. Similarities between human and rat leukocyte elastase and cathepsin G. Eur J Biochem. 1984; 144 1-9

Crossref PubMed Search in Google Scholar
243 Fritz H, Wunderer G. Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs. Arzneim. Forschung / Drug Res. 1983; 33 479-494

PubMed Search in Google Scholar
244 Högström H, Haglund U, Zederfeldt B. Beneficial effect on intestinal anastomoses of S-2441, a synthetic kallikrein-kinin antagonist. Experimental studies in the rat. Am J Surg. 1985; 150 312-314

Crossref PubMed Search in Google Scholar
245 Ryan G B, Majno G. Acute Inflammation. Am J Pathol. 1977; 86 183-276

PubMed Search in Google Scholar
246 Högström H, Haglund U. Early decrease in suture line breaking strength. The effect of proposed collagenase inhibition. Res Exp Med. 1985; 185 451-455

Crossref PubMed Search in Google Scholar
247 Stewart R. Influence of malignant cells on the healing of colonic anastomoses: experimental observations. Proc Roy Soc Med. 1973; 66 1089-1091

PubMed Search in Google Scholar
248 Hawley P R. Cancer of the colon and rectum: Collagenase activity in patients who have rectal carcinoma. Dis Colon Rectum. 1976; 19 9-10

PubMed Search in Google Scholar
249 Albertson S, Hummel III R P, Breeden M, Greenhalgh D G. PDGF and FGF reverse the healing impairment in protein-malnourished diabetic mice. Surgery. 1993; 114 368-373

PubMed Search in Google Scholar
250 Beickert R, von Imhoff C. Nahtinsuffizienz am Dickdarm: Ist der Operateur ein Risikofaktor?. Chirurg. 1984; 55 645-649

PubMed Search in Google Scholar
251 Brennan S S, Pickford I R, Evans M, Pollock A V. Staples or sutures for colonic anastomoses. A controlled clinical trial. Br J Surg. 1982; 69 722-724

PubMed Search in Google Scholar
252 Gilmour D G, Aitkenhead A R, Hothersall A P, Mc A. Ledingham I. The effect of hypovolaemia on colonic blood flow in the dog. Br J Surg. 1980; 67 82-84

PubMed Search in Google Scholar
253 Irvin T T, Goligher J C. Aetiology of disruption of intestinal anastomoses. Br J Surg. 1973; 60 461-464

PubMed Search in Google Scholar
254 Kühlmayer R, Doberauer B. Die letale Nahtdehiszenz als Risikofaktor der Kolon-Rektumchirurgie. Wien Med Wschr. 1981; 131 395-399

PubMed Search in Google Scholar
255 Stelzner F. Vorbeugung der intraperitonealen Nahtinsuffizienz (Dünn- und Dickdarm). Langenbecks Arch Chir. 1982; 358 259-263

PubMed Search in Google Scholar
256 Wayand W, Rieger R, Umlauft M. Ein- oder zweireihig? Eine kontrollierte prospektive Studie zum Vergleich zweier Nahttechniken bei gastrointestinalen Anastomosen. Chirurg. 1984; 55 650-652

PubMed Search in Google Scholar
257 Athanasiadis S, Girona J, Gandji D, Lutfi T. Die Bedeutung der Nahttechnik in der Darmchirurgie. In: Thiede A, Hamelmann H (Hrsg) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer Berlin Heidelberg New York; 1982: S. 199-207

Search in Google Scholar
258 Beickert R, von Imhoff C. Nahtinsuffizienz am Dickdarm: Ist der Operateur ein Risikofaktor?. Chirurg. 1984; 55 645-649

PubMed Search in Google Scholar
259 Eichfuss H P, Knipper A. Wundheilung am Darm bei akuter und chronischer Peritonitis. In: Häring R (Hrsg) Peritonitis. TM Bad Oeynhausen; 1979: S 154-157

Search in Google Scholar
260 Merkle P. Entero-enterale Anastomosen. Chirurg. 1984; 55 632-637

PubMed Search in Google Scholar
261 Meyer G, Lange V, Oevermann E, Schildberg F W. Notfallchirurgie beim kolorektalen Karzinom: Risikofaktoren, onkologischer Stellenwert und therapeutische Möglichkeiten. In: Hollender LF, De Manzini N (Eds) Chirurgie d’urgence. Tome I 1990: pp 413-415

Search in Google Scholar
262 Slavin J, Nash J R, Kingsnorth A N. Effect of transforming growth factor beta and basic fibroblast growth factor on steroid-impaired healing intestinal wounds. Br J Surg. 1992; 79 69-72

PubMed Search in Google Scholar
263 Wilker D, Sklarek J, Waldner H, Izbicki J R, Siebeck M. Untersuchung zur Frühphase der Anastomosenheilung unter besonderer Berücksichtigung von Peritonitis und Ischämie. Langenbecks Arch Chir. 1988; 373 217-221

PubMed Search in Google Scholar
264 Christensen H, Oxlund H, Laurberg S. Postoperative biosynthetic human growth hormone increases the strength and collagen deposition of experimental colonic anastomoses. Int J Colorect Dis. 1991; 6 133-138

Crossref PubMed Search in Google Scholar
265 Goodman L, Stein G H. Basal and induced amounts of interleukin-6 mRNA decline progressively with age in human fibroblasts. J Biol Chem. 1994; 269 19 250-19 255

PubMed Search in Google Scholar
266 Hamon G A, Hunt T K, Spencer E M. In vivo effects of systemic insulin-like growth factor-I alone and compleated with insulin-like growth factor binding protein-3 on corticosteroid suppressed wounds. Growth Regul. 1993; 3 53-56

PubMed Search in Google Scholar
267 Kingsnorth A N, Vowles R, Nash J RG. Epidermal growth factor increases tensile strength in intestinal wounds in pigs. Br J Surg. 1990; 77 409-412

PubMed Search in Google Scholar
268 Watson R WG, Redmond H P, Mc Carthy J, Burke P E, Bouchier-Hayes D. Exposure of the peritoneal cavity to air regulates early inflammatory responses to surgery in a murine model. Br J Surg. 1995; 82 1060-1065

PubMed Search in Google Scholar
269 Hofstädter F. Pathologie der Wundheilung. Chirurg. 1995; 66 174-181

PubMed Search in Google Scholar
270 Zederfeldt B. Anastomotic Healing. In: Eigler FW, Gross E, Vogt E (Hrsg) Die Anastomose am Gatrointestinaltrakt. TM Hameln; 1990: S 13-16

Search in Google Scholar
271 Meßmer K, Wanner K, Reulen H J. Durchblutungsverhalten abdomineller Organe nach Endotoxininjektion beim Hund. Z Ges Exp Med. 1968; 146 292-308

PubMed Search in Google Scholar
272 Leder L D. Wundheilung und Fremdkörperreaktion. In: Thiede A, Hamelmann H (Hrsg) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer Berlin Heidelberg New York; 1982: S226-228

Search in Google Scholar
273 Lindner J. Morphologie und Biochemie der Wundheilung. Langenbecks Arch Chir (Kongreßbericht 1982). 1982; 358 153-160

PubMed Search in Google Scholar
274 Schäfer K, Stanka H, Ernst R, Zumtobel V. Ausdehnung und Bedeutung von Mikrozirkulationsstörungen für die Pathogenese der Nahtinsuffizienz bei Colonanastomosen. In: Eigler FW, Gross E, Vogt E (Hrsg) Die Anastomose am Gastrointestinaltrakt. TM Hameln; 1990: S 39-47

Search in Google Scholar
275 Graham M F, Drucker D EM, Diegelmann R F, Elson C O. Collagen synthesis by human intestinal smooth muscle cells in culture. Gastroenterology. 1987; 92 400-405

PubMed Search in Google Scholar
276 Peterkofsky B. Ascorbate requirement for hydroxylation and secretion of procollagen: relationship to inhibition of collagen synthesis in scurvy. Am J Clin Nutr. 1991; 54 1135S-1140S

PubMed Search in Google Scholar
277 Bark S, Rettura G, Goldman D, Seifter E, Levenson S, Demetriou A A. Effect of supplemental vitamin A on the healing of colon anastomosis. J Surg Res.. 1984; 36 470-474

Crossref PubMed Search in Google Scholar
278 Winsey K, Simon R J, Levenson S M, Seifter E, Demetriou A A. Effect of supplemental vitamin A on colon anastomotic healing in rats given preoperative irradiation. Am J Surg. 1987; 153 153-156

Crossref PubMed Search in Google Scholar
279 Daly J M, Vars H M, Dudrick S J. Effects of protein depletion on strength of colonic anastomoses. Surg Gynecol Obstet. 1972; 134 15-21

PubMed Search in Google Scholar
280 Preshaw R M, Attisha R P, Hollingsworth W J, Todd J D. Randomized sequential trial of parenteral nutrition in healing of colonic anastomoses in man. Can J Surg. 1979; 22 437-439

PubMed Search in Google Scholar
281 Rahmat A, Norman J N, Smith G. The effect of zinc deficiency on wound healing. Br J Surg. 1974; 61 271-273

PubMed Search in Google Scholar
282 Jochum M, Witte J, Schiessler H, Selbmann H K, Ruckdeschl G, Fritz H. Clotting and other plasma factors in experimental endotoxemia: inhibition of degradation by exogenous proteinase inhibitors. Eur Surg Res. 1981; 13 152-168

PubMed Search in Google Scholar
283 Müller-Berghaus G. Pathophysiology of generalized intravascular coagulation. Semin Thromb Hemost. 1977; 3 209-246

PubMed Search in Google Scholar
284 Greuer W, Hee E, Klein-Buchholz F, Marggraf G, Quadripur S, Stankovic P, Weber H G, Wilde G. Spontane periphere Proteolyse. 1. Mitteilung: Methodik und klinische Untersuchungsergebnisse. Surg Res. 1976; 26 89-103

PubMed Search in Google Scholar
285 Haverkate F, Brakman P. Fibrin plate essay. Progr Chem Fibrinol Thrombol. 1975; 1 151-162

PubMed Search in Google Scholar
286 Rotstein D, Pruett T L, Simmons R L. Fibrin in peritonitis. Ann Surg. 1986; 203 413-419

PubMed Search in Google Scholar
287 Högström H, Claeson G, Larsson-Backström C, Lundberg D, Wenngren E, Haglund U. Septic shock in the rat: Activation of plasma proteolytic systems and effects of a kallikrein inhibitor/bradykinin antagonist (S-2441). Acta Chir Scand. 1987; 153 161-164

PubMed Search in Google Scholar
288 Tagart R EB. Colorectal anastomosis: factors influencing success. J R Soc Med. 1981; 74 111-118

PubMed Search in Google Scholar
289 Scheele J, Husemann B, Pesch H J. Kolonanastomosen im Tierexperiment. Mechanische und morphologische Befunde. Z Exp Chir. 1978; 11 110-120

PubMed Search in Google Scholar
290 Lee E. The effect of obstructive jaundice on the migration of reticulo-endothelial cells and fibroblasts into early experimental granulomata. Br J Surg. 1972; 59 875-877

PubMed Search in Google Scholar
291 Than T, McGee J O’D, Sokhi G S, Patrick R S, Blumgart L H. Skin prolyl hydroxylase in patients with obstructive jaundice. Lancet. 1974; 2 807-808

PubMed Search in Google Scholar

PD Dr. G. Meyer

Chirurgische Klinik und Poliklinik
Klinikum Großhadern

Marchioninistr. 15

81377 München

Phone: 089 - 7095 - 3570

Fax: 089 - 7095 - 8894

Email: meyerg@gch.med.uni-muenchen.de