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Synlett 2001; 2001(Special Issue): 0923-0926
DOI: 10.1055/s-2001-14667
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Ferrocenyl Thiolates as Ligands in the Enantioselective Copper-Catalyzed Substitution of Allylic Acetates with Grignard Reagents

A. Sofia E. Karlström* , Fernando F. Huerta, Gerrit J. Meuzelaar, Jan-E. Bäckvall
  • *Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden; Fax + 46-8-8 15 49 08; E-mail: jeb@organ.su.se
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Publication Date:
31 December 2001 (online)

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The application of ferrocenyl thiolates as ligands in copper-catalyzed asymmetric substitution reactions of allylic acetates with Grignard reagents is reported. The catalyst from lithium thiolate 12 gave the γ-products in high selectivity and with up to 64% ee.

asymmetric synthesis - copper - ferrocenyl ligands - sulfur - asymmetric catalysis