Synthesis of N ^α -Tetrachlorophthaloyl (TCP)-Protected Amino Acids under Microwave Irradiation (MWI)

Abstract

A range of N ^α-tetrachlorophthaloyl protected amino acids have been synthesized by an easy and efficient condensation procedure of the corresponding amino acid and tetrachlorophthaloyl anhydride under irradiation in an unmodified commercial microwave oven.

Key words

amino acids - microwave irradiation - protecting groups - phthalimide - tetrachlorophthaloyl

References and Notes

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11

PAL, peptide amide linker: 5-(4-aminomethyl-3,5-dimethoxyphenoxy)valeric acid; PEG-PS, polyethylene glycol-polystyrene (graft support).

12

Continuous heating resulted in burning of the reaction mixture.