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Horm Metab Res 2001; 33(5): 256-262
DOI: 10.1055/s-2001-15280
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© Georg Thieme Verlag Stuttgart · New York

Regulation of Renal Growth and IGFBP-4 Expression by Triiodothyronine During Rat Development

A. Voci, I. Demori, C. Bottazzi, E. Fugassa
  • Dipartimento di Biologia Sperimentale, Ambientale ed Applicata - Sezione di Fisiologia Generale e Comparata, Università di Genova, Italy
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Publication History

Publication Date:
31 December 2001 (online)

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The insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs), which regulate IGF activity, play a fundamental role in renal cell proliferation and differentiation. The thyroid hormone is considered to be required for kidney development; excess induces local hypertrophy and hyperplasia. The aim of the present study was to investigate the possible involvement of the IGF/IGFBP system in thyroid hormone-induced renal growth during the development of the rat. Our results show that thyroid hormone withdrawal by 6-propyl-2-thiouracil (PTU)-treatment of rats at all ages had no effect on renal IGFBP-4 mRNA levels, whereas the abundance of the serum protein was decreased compared to controls. Intraperitoneal triiodothyronine (T3) administration to hypothyroid rats resulted in renal hypertrophy associated with a significant upregulation of IGFBP-4 expression with increased levels of renal IGFBP-4 mRNA and serum protein. T3-induced upregulation of IGFBP-4 expression suggests the involvement of the local IGF/IGFBP system in T3-induced renal hypertrophy.

Key words:

Triiodothyronine - IGFBP-4 - Kidney Hypertrophy

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A. Voci

Dipartimento di Biologia Sperimentale
Ambientale ed Applicata sezione di
Fisiologia Generate e Comparata

Palazzo delle Scienze - corso Europa 26
16132 Genova
Italy


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