Two New Bislabdane-Type Diterpenoids and Three New Diterpenoids from the Roots of Cunninghamia lanceolata

Abstract

Two new bislabdane-type diterpenoids lanceolatin (1), lancelatol (2) and three new diterpenoids 15-nor-14-oxo-8(17),12-labdanien-14,18-dionic acid (3), 8(17),12,14-labdantrien-18-oic acid (4) and 8(17),12,14-labdantrien-18-ol (5), together with 7 known diterpenoids were isolated from the roots of Cunninghamia lanceolata. Their structures were determined by spectroscopic and chemical methods. All of these compounds were isolated from the species for the first time. One of the isolated compounds showed a significant inhibition effect on mouse hind-paw edema induced by carrageenan.

Key words

Cunninghamia lanceolata - Taxodiaceae - bislabdane-type diterpenoid - lanceolatin - lanceolatol - 15-nor-14-oxo-8(17), 12-labdandien-14,18-dioic acid - 8(17),12,14-labdantrien-18-oic acid - 8(17),12,14-labdantrien-18-ol

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