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Synlett 2001; 2001(9): 1423-1427
DOI: 10.1055/s-2001-16780
DOI: 10.1055/s-2001-16780
letter
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Synthesis of SB-214857 using Copper Catalysed Amination of Arylbromides with l-Aspartic Acid
Further Information
Publication History
Publication Date:
28 August 2001 (online)
An efficient synthesis of a 1,4-benzodiazepine was accomplished using copper catalysed amination of an arylbromide with the soluble bis-tetrabutylammonium salt of l-aspartic acid as a key step.
copper catalysis - aromatic amination - amino acids - benzodiazepines - SB-214857