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Synlett 2001; 2001(9): 1440-1442
DOI: 10.1055/s-2001-16790
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Efficient and Flexible Access to Polysubstituted Pyrroles

Claude Agami* , Luc Dechoux, Séverine Hebbe
  • *Laboratoire de Synthèse Asymétrique associé au CNRS, Université Pierre et Marie Curie, 4 place Jussieu, 75005 Paris, France; Fax (33) 01 44 27 26 20; E-mail: dechoux@ccr.jussieu.fr
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Publication Date:
28 August 2001 (online)

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A series of polysubstituted pyrroles 3 have been synthesized very efficiently in two or three steps starting from primary amines 1. The key-step of this process is the bromocyclisation of δ-enaminoesters 2. The chemoselectivity of the reaction could depend on the nature of the solvent.

pyrroles - δ-enaminoesters - β-enaminoesters - bromocyclisation - amines