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Synthesis 2001(12): 1851-1855
DOI: 10.1055/s-2001-17516
DOI: 10.1055/s-2001-17516
PAPER
© Georg Thieme Verlag Stuttgart · New York
One-Pot Preparation of Pyranoquinolinones by Ytterbium(III) Trifluoromethanesulfonate-Catalyzed Reactions: Efficient Synthesis of Flindersine, N-Methylflindersine, and Zanthosimuline Natural Products
Further Information
Received
14 May 2001
Publication Date:
11 August 2004 (online)
Publication History
Publication Date:
11 August 2004 (online)
Abstract
An efficient synthesis of pyranoquinolinones is achieved by ytterbium(III) triflate-catalyzed reaction of 4-hydroxy-2-quinolones with a variety of α,β-unsaturated aldehydes in moderate yields. This new method has been applied to the synthesis of pyranoquinolinone alkaloids.
Key words
pyranoquinolinone alkaloids - Yb(OTf)3 - flindersine - N-methylflindersine - zanthosimuline
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