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Synlett 2001; 2001(12): 1932-1934
DOI: 10.1055/s-2001-18738
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A Method for Selective N-Boc Deprotection on Wang Resin

Harish S. Trivedi* , Mike Anson, Patrick G. Steel, Justin Worley
  • *Chemical Development, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK; E-mail: hst3634@gsk.com
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Publication Date:
04 December 2001 (online)

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A simple, inexpensive and efficient method for the selective cleavage of N-Boc protecting group under acidic conditions on high load Wang resin is described. This method employs the use of concd sulfuric acid in 1,4-dioxan and provides an efficient process for the complete Boc deprotection with minimal loss of substrate through cleavage from resin.

solid phase synthesis - selective N-Boc cleavage - high load Wang resin