Download PDF
Synlett 2001; 2001(12): 1893-1896
DOI: 10.1055/s-2001-18739
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

One-pot Three-step Solution Phase Syntheses of Thiohydantoins using Microwave Heating

Liselotte Öhberg* , Jacob Westman
  • *SIK AB, Uppsala Science Park, SE-751 83 Uppsala, Sweden; Fax: + 46 (18) 4899200; E-mail: jacob:WESTMAN>?§>personalchemistry.com
Further Information

Publication History

Publication Date:
04 December 2001 (online)

  PDF Download  Permissions and Reprints All articles of this category

An efficient one-pot three-step solution phase protocol suitable for library syntheses of thiohydantoins was developed. The reactions included are in the following order, Negishi or Suzuki C-C coupling reactions, reductive amination and finally a cyclisation reaction. Protocols using a solid supported reagent and protocols suitable for combinatorial chemistry were developed, all including microwave heating.

microwave heating - solid supported reagents - one-pot synthesis