Planta Med 2001; 67(9): 873-875
DOI: 10.1055/s-2001-18838
Letter

© Georg Thieme Verlag Stuttgart · New York

Antifungal Principles from Piper fulvescens

Blanca Freixa1 , Roser Vila1 , Esteban A. Ferro2 , Tomás Adzet1 , Salvador Cañigueral1
  • 1 Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain
  • 2 Facultad de Ciencias Químicas, Universidad de Asunción, Asunción, Paraguay
Further Information

Publication History

December 12, 2000

February 4, 2001

Publication Date:
06 December 2001 (online)

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Abstract

Activity-guided fractionation of the dichloromethane extract from leaves of Piper fulvescens, using an agar overlay bioautographic method, led to the isolation of three antifungal neolignans identified as conocarpan, eupomatenoid 5 and eupomatenoid 6. The minimal inhibitory concentration of these three neolignans against five fungi strains were determined. Conocarpan showed the widest activity, whereas eupomatenoid 6 was the most active against dermatophytes.