Download PDF
Synthesis 2001; 2001(1): 0046-0048
DOI: 10.1055/s-2001-9755
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Short and Efficient Synthesis of (S)-1-Boc-2,5-dihydro-1H-pyrrole-2-carboxylic Acid

R. Stürmer* , B. Schäfer, V. Wolfart, H. Stahr, U. Kazmaier, G. Helmchen
  • *BASF AG, Hauptlaboratorium, Carl-Bosch-Straße 38, 67056 Ludwigshafen, Germany; Fax +49(621)6 04 22 90; E-mail: bernd2.schaefer@knoll-ag.de
Further Information

Publication History

Publication Date:
31 December 2001 (online)

  PDF Download  Permissions and Reprints All articles of this category

A short and efficient synthesis of (S)-1-Boc-2,5-dihydro-1H-pyrrole-2-carboxylic acid is described. Starting from N-Boc-diallylamine, the synthesis involves ring-closing metathesis (RCM), directed alkoxycarbonylation (using strong lithium bases and alkyl carbonates) and enzymatic kinetic resolution of the racemate.

alkoxycarbonylation - enzymes - lithiation - metathesis - kinetic resolution