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Planta Med 2002; 68(2): 101-105
DOI: 10.1055/s-2002-20250
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Furanoligularenone, an Eremophilane from Ligularia fischeri, Inhibits the LPS-Induced Production of Nitric Oxide and Prostaglandin E2 in Macrophage RAW264.7 Cells

Bang Yeon Hwang1, 2 , Jeong-Hyung Lee1 , Tae Hyeon Koo1 , Hang Sub Kim1 , Young Soo Hong1 , Jai Seup Ro2 , Kyong Soon Lee2 , Jung Joon Lee1
  • 1Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
  • 2College of Pharmacy, Chungbuk National University, Cheongju, Korea
Further Information

Publication History

March 29, 2001

June 10, 2001

Publication Date:
22 February 2002 (online)

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Abstract

Furanoligularenone (1), a known eremophilane, was identified from Ligularia fischeri (Compositae) together with 3-oxo-8α-hydroxy-10αH-eremophila-1,7(11)-dien-12,8β-olide (2) and 3-oxo-8α-methoxy-10αH-eremophila-1,7(11)-dien-12,8β-olide (3), by its potent inhibition of LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 cells. Compound 1 also suppressed the expression of iNOS and COX-2 mRNA and protein in a dose-dependent manner. Taken together, compound 1 inhibits the production of NO and PGE2 at the transcription of iNOS and COX-2 genes, and would be responsible for the anti-inflammatory activities of the Ligularia fischeri.

Key words

Ligularia fischeri - Compositae - furanoligularenone - nitric oxide - prostaglandin E2 - inducible nitric oxide synthase - cyclooxygenase-2 - NF-κB

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Dr. Jung Joon Lee

Anticancer Research Laboratory

Korea Research Institute of Bioscience and Biotechnology

P.O. Box 115

Yusong

Taejon 305-600

Korea

Email: jjlee@mail.kribb.re.kr

Fax: +82-42-860-4595