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Horm Metab Res 2002; 34(5): 271-274
DOI: 10.1055/s-2002-32142
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

Acute Effects of Valsartan on Insulin Sensitivity in Obese, Non-Hypertensive Subjects with and without Type 2 Diabetes

S.  D.  Luzio1 , G.  Dunseath1 , D.  R.  Owens1
  • 1Diabetes Research Unit, Llandough Hospital, Penarth, UK
Further Information

Publication History

18 July 2001

29 January 2002

Publication Date:
10 June 2002 (online)

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Abstract

Background: Two studies were designed to determine whether a single dose (80 mg) of the angiotensin II receptor blocker (ARB), valsartan, alters insulin sensitivity in obese, non-hypertensive subjects with and without Type 2 diabetes. Methods: Insulin sensitivity (SI), glucose effectiveness (SG), and acute insulin response (AIR0 - 10 min) were measured by means of a 3-hour insulin-modified frequently sampled intravenous glucose tolerance test (FSIVGTT) before and after a single dose of valsartan. Study 1: obese, normotensive non-diabetic male subjects (n = 12), mean (SD) age 37.2 ± 11.2 years, BMI 32.8 ± 6.8 kg/m2; Study 2: obese, normotensive Type 2 diabetic patients (n = 12), mean age 55.7 ± 6.9 years, BMI 35.0 ± 6.8 kg/m2/l. Both studies were randomised, double-blind, placebo-controlled, single-dose crossover group studies involving subjects in two study days, two weeks apart. After fasting samples were taken, a 300 mg/kg iv glucose bolus was injected at 0 min, and 0.05 U/kg iv insulin was given 20 min later. Blood samples for analysis of glucose and insulin were taken throughout the 3-hour study period. Results: Study 1 (non-diabetic subjects) SI 2.81 vs. 2.63 × 10-4 min-1 per µU/ml (p = 0.54), SG 0.020 vs. 0.020 min-1 (p = 0.90), AIR0 - 10 min 3305 vs. 3450 µU/min/ml (p = 0.71); Study 2 (patients with type 2 diabetes) SI 0.59 vs. 0.85 × 10-4 min-1 per µU/ml (p = 0.15), SG 0.013 vs. 0.014 min-1 (p = 0.71), AIR0 - 10 min 65 vs. 119 µU/min/ml (p = 0.14), placebo vs. valsartan, respectively. Conclusion: In obese, non-hypertensive non-diabetic and Type 2 diabetic subjects a single dose of valsartan does not alter insulin sensitivity.

Key words

Valsartan - Insulin Sensitivity - Healthy Subjects - Type 2 Diabetes

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Dr. S. D. Luzio

Diabetes Research Unit · Llandough Hospital

Penlan Road · Penarth · S Glam · CF64 2XX · UK

Phone: + 29-20716927

Fax: + 29-20350147

Email: luzio@cf.ac.uk