Pd/C-H₂-Catalysed Deuterium Exchange Reaction of the Benzylic Site in D₂O

Abstract

Pd/C is found to catalyse efficient and chemoselective exchange of deuterium derived from D₂O with hydrogens on a benzylic carbon in the presence of a catalytic amount of hydrogen at room temperature.

Key words

catalysis - chemoselectivity - deuterium exchange - deuterium labelled compounds - palladium on carbon

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10

The reaction in CD₃OD also gave similar result and the detail will be reported in due course.

11

Shorter reaction time (1 d) leads to drastic decrease of the deuterium incorporation (48%).