Rett Females: Patterns of Characteristic Side-Asymmetric Neuroimpairments at Long-Term Follow-Up

Abstract

From a follow-up series of 24 classical Rett syndrome females (13 - 59 years of age), side asymmetries of neuroimpairments were systematically investigated. A characteristic right-sided dominance in terms of dysfunction and neurology was revealed. Differences in the perinatal/early postnatal development of finer brain net structures between brain halves are suggested as a possible explanation.

Key words

Rett Syndrome - Adulthood - Neuroimpairments - Side Asymmetries

References

• 1 Armstrong D D. The neuropathology of Rett syndrome - Overview 1994.  Neuropediatrics. 1995;  26 100-104
• 2 Armstrong D D. Rett syndrome neuropathology review 2000.  Brain Dev. 2001;  23 S72-S76
• 3 Bishop D VM. Handedness and developmental disorder. Clinics in Developmental Medicine. No 110. Oxford; MacKeith Press 1990
• 4 Gillberg C H. Autistic children's hand preferences: results from an epidemiological study of infantile autism.  Psychiatry Research. 1983;  10 21-30
• 5 Gordon N. Left-handedness and learning.  Dev Med Child Neurol. 1986;  28 649-661
• 6 Hagberg B. Rett syndrome - clinical and biological aspects. Clinics in Developmental Medicine. No 127. Cambridge; MacKeith Cambridge University Press 1993
• 7 Hagberg B, Skjeldal O H. Rett variants: a suggested model for inclusion criteria.  Pediatr Neurol. 1994;  11 5-11
• 8 Nomura Y, Segawa M, Hasegawa M. Rett syndrome - Clinical studies and pathophysiological considerations.  Brain Dev. 1984;  6 475-486
• 9 Olsson B, Rett A. Shift to righthandedness in Rett syndrome around age 7.  Am J Med Genet. 1986;  24 133-141
• 10 Yokochi K, Shimabukuro S, Kodama M, Hosoe A. Dominant use of the left hand by athetotic cerebral palsied children.  Brain Dev. 1990;  12 807-808