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Horm Metab Res 2002; 34(11/12): 659-663
DOI: 10.1055/s-2002-38253
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

Relationship between IL-6, Leptin and Adiponectin and Variables of Fibrinolysis in Overweight and Obese Hypertensive Patients

T.  Skurk 1 , V.  van Harmelen 1 , Y.-M.  Lee 1 , A.  Wirth 2 , H.  Hauner 1
  • 1 German Diabetes Research Institute at the Heinrich-Heine-University, Düsseldorf, Germany
  • 2 Teutoburger-Wald-Klinik, Bad Rothenfelde, Germany
Further Information

Publication History

Received 17 October 2002

Accepted after revision 3 December 2002

Publication Date:
27 March 2003 (online)

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Abstract

Impaired fibrinolysis is a common finding in obese humans. This condition is now considered as an established risk factor for thromboembolic complications. Furthermore, obesity is characterized by a specific pattern of circulating concentrations of fat-cell products interleukin-6 (IL-6), leptin, and adiponectin. The aim of our study was to investigate the relationship between these proteins and selected variables of the fibrinolytic system in 74 mildly hypertensive, overweight subjects. Circulating IL-6 and leptin levels showed a positive association with BMI (r = 0.24, p = 0.04 and r = 0.70, p < 0.0001), whereas adiponectin was not correlated to BMI. Interestingly, IL-6 was also positively associated with t-PA/PAI-1 complexes after adjustment for BMI and other anthropometric variables. Leptin was positively correlated with PAI-1 activity and antigen (r = 0.32, p = 0.006 and r = 0.37, p < 0.001, respectively) and negatively with t-PA activity (r = -0.27, p = 0.03). However, these associations lost significance after correction for BMI or HOMA, an insulin sensitivity index. In contrast, adiponectin levels were independently and negatively correlated with PAI-1 antigen (r = -0.26, p = 0.04, after correction for BMI). In conclusion, our study provides further evidence that IL-6, leptin, and adiponectin are associated with impaired fibrinolysis in overweight hypertensive humans.

Key words

Fibrinolysis - Obesity - Interleukin-6 - Leptin - Adiponectin

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T. Skurk, M.D.

Clinical Department

German Diabetes Research Institute · Heinrich-Heine-University Düsseldorf · Auf’m Hennekamp 65 · 40225 Düsseldorf · Germany ·

Phone: + 49 (211) 33 82-1

Fax: + 49 (211) 33 82-339

Email: skurk@ddfi.uni-duesseldorf.de