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DOI: 10.1055/s-2003-37492
J. A. Barth Verlag in Georg Thieme Verlag Stuttgart · New York
Leptin Resistance - Or Why Leptin Fails to Work in Obesity
Publication History
Received: May 16, 2002
First decision: July 22, 2002
Accepted: August 20, 2002
Publication Date:
26 February 2003 (online)
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Abstract
In experimental models of obesity high serum concentrations of leptin without subsequent inhibition of food intake indicate a resistance to the physiological effects of leptin. Similar to the animal model leptin concentrations in most of the obese patients are higher compared to normal-weight persons. The postulated leptin resistance is one major target in the search for a better understanding of obesity and the development of pharmacological tools to treat this spreading disease.
Key words
Leptin - Leptin resistance - STAT3 - SOCS3 - Blood-brain-barrier
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Hendrik Lehnert
Department of Endocrinology and Metabolism · Otto-Von-Guericke University
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