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Planta Med 2003; 69(3): 267-269
DOI: 10.1055/s-2003-38493
Letter
© Georg Thieme Verlag Stuttgart · New York

Antiplatelet Activities of Aporphine Alkaloids Isolated from Leaves of Magnolia obovata

Mi Kyung Pyo1 , 3 , Hye Sook Yun-Choi1 , Young-Jin Hong2
  • 1Natural Products Research Institute, Seoul National University, Seoul, Korea
  • 2College of Medicine, Inha University, Inchon, Korea
  • 3Present address: E.S. Life Science Research Institute, Seoul, Korea
Further Information

Publication History

Received: June 24, 2002

Accepted: December 22, 2002

Publication Date:
04 April 2003 (online)

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Abstract

Five aporphine alkaloids, N-acetylanonaine (1), N-acetylxylopine (2), N-formylanonaine (3), liriodenine (4), and lanuginosine (5) as the antiplatelet constituents, were isolated from the methanol extract of leaves of Magnolia obovata. This is the first reported occurrence of 2 and 3 from genus Magnolia and 5 was isolated from this plant for the first time. Compounds 1, 2 and 3 showed 60 ∼ 264-fold stronger inhibitory effects than acetylsalicylic acid (ASA) to rat platelet aggregation induced by collagen, epinephrine, arachidonic acid (AA), or U46619.

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Hye Sook Yun-Choi

Natural Products Research Institute

Seoul National University

Seoul 110-460

Korea

Phone: +82-2-740-8923

Fax: +82-2-766-7818

Email: hsyun@snu.ac.kr