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Planta Med 2003; 69(5): 464-467
DOI: 10.1055/s-2003-39705
Letter
© Georg Thieme Verlag Stuttgart · New York

Studies on Di- and Triterpenoids from Salvia staminea with Cytotoxic Activity

Gulacti Topcu1 , Esra N. Altiner2 , Seyda Gozcu2 , Belkis Halfon2 , Zeynep Aydogmus1 , 3 , J. M. Pezzuto3 , Bing-Nan Zhou4 , David G. I. Kingston4
  • 1Istanbul University, Faculty of Pharmacy, Istanbul, Turkey
  • 2Bogazici University, Department of Chemistry, Istanbul, Turkey
  • 3Program for Collaborative Research in Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, IL, USA
  • 4Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
Further Information

Publication History

Received: August 14, 2002

Accepted: December 31, 2002

Publication Date:
12 June 2003 (online)

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Abstract

A new ursane-type triterpenoid, 3β,11α,21α-trihydroxyurs-12-ene, named salvistamineol (1), has been isolated from the methanol extract of Salvia staminea. In addition to 1, the methanol extract yielded four known compounds and the acetone extract yielded twelve known compounds consisting of two sesquiterpenes, six diterpenoids, a triterpenoid, two steroids and one flavone. DNA damaging properties of the extracts and some isolated diterpenes were investigated against three yeasts and only taxodione gave a positive response and also showed the highest cytotoxic activity against a panel of cell lines among the investigated compounds in this study.

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Prof. Dr. Gülaçti Topcu

Istanbul University

Faculty of Pharmacy

34452 Beyazit-Istanbul

Turkey

Email: gulacti_topcu@hotmail.com

Fax: +90-212-519 08 12