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Synlett 2003(8): 1183-1185
DOI: 10.1055/s-2003-39886
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Improved Synthesis of Substituted Quinoxalines from New N=N-Polymer-bound 1,2-Diaza-1,3-butadienes

Orazio A. Attanasi, Lucia De Crescentini, Paolino Filippone*, Fabio Mantellini*, Stefania Santeusanio
Istituto di Chimica Organica, Università degli Studi di Urbino, Piazza della Repubblica 13, 61029 Urbino, Italy
Fax: +39(0722)2907; e-Mail: filippone@uniurb.it;
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Publication History

Received 20 March 2003
Publication Date:
11 June 2003 (online)

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Abstract

The first general protocol for the preparation of different N=N-polymer-bound 1,2-diaza-1,3-butadienes is reported. The utility of these supported reagents in the solid-phase in the preparation of 3-methyl quinoxaline-2-carboxylates by reaction with aromatic 1,2-diamines is presented.

Key words

1,2-diaza-1,3-butadienes - hydrazones - Michael addition - quinoxalines - solid-phase synthesis

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