Abstract
The identification and development of a catalyst for the enantioselective
nucleophilic addition of a trifluoromethyl anion to a ketone is
described. An easily prepared cinchonine-derived catalyst was used
in amounts as low as 4 mol% to afford enantiomeric excess
as high as 92%.
Key words
alkaloids - ketones - aldehydes - asymmetric
catalysis - fluorine - nucleophilic additions - substituent effects
References
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