New Cobalt-Catalyzed Cross-Coupling Reactions of Heterocyclic Chlorides with Aryl and Heteroaryl Magnesium Halides

Abstract

New cobalt-catalyzed cross-coupling between arylmagnesium halides and 2-chloropyridines and related heterocycles occur at low temperature leading to 2-arylated heterocycles in good yields.

Key words

cobalt-catalysis - cross-coupling - organomagnesium reagents - arylation - heterocycles

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11

Commercially cobalt powder was used (Aldrich, 99.9+% purity).

12

Commercially iron powder was used (Merck, 99.5% purity).