Abstract
The use of 2-naphthalenemethyl (NAP) as a versatile amino protecting group is reported.
Highly efficient and chemoselective cleavage of protected tertiary amines using DDQ
in CH2 Cl2 -MeOH (4:1) has been observed in the presence of various functionalities such as hydroxyl,
acetal, alkene, ester, benzyloxy and N -benzyl groups.
Key words
protecting group - amine - 2-naphthalenemethyl (NAP) group - oxidative cleavage -
DDQ
References
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