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Synthesis 2004(1): 43-52
DOI: 10.1055/s-2003-44376
DOI: 10.1055/s-2003-44376
PAPER
© Georg Thieme Verlag Stuttgart · New York
Regioselective Synthesis of 1,3,5-Substituted Pyrazoles from Acetylenic Ketones and Hydrazines
Further Information
Received
6 October 2003
Publication Date:
17 December 2003 (online)
Publication History
Publication Date:
17 December 2003 (online)
Abstract
The synthesis of diversely substituted 1,3,5-substituted pyrazoles from the reaction of acetylenic ketones with substituted hydrazines is reported. The reactions were shown to be highly regioselective regardless of the nature of the substituents in the substrates and afforded essentially single pyrazole isomers in excellent yields.
Key words
pyrazoles - ketones - alkynes - hydrazones - regioselectivity
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