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Synthesis 2004(1): 17-19  
DOI: 10.1055/s-2003-44377
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

New Cyclizing Reagent for the Synthesis of 1,3,4-Thiadiazoles

Vladimir N. Yarovenko*, Aleksandr V. Shirokov, Igor V. Zavarzin, Oksana N. Krupinova, Anatolii V. Ignatenko, Mikhail M. Krayushkin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russia
Fax: +7(95)135 5328; e-Mail: yarov@mail.ioc.ac.ru;
Further Information

Publication History

Received 27 August 2003
Publication Date:
17 December 2003 (online)

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Abstract

A new cyclizing reagent is proposed for the synthesis of 5-unsubstituted 1,3,4-thiadiazoles. The latter are formed in good yields by the reactions of thiohydrazides with diethyl chlorophosphate in DMF.

Key words

oxamic thiohydrazides - diethyl chlorophosphate - phosphorus oxychloride - dimethylformamide - unsubstituted carbamoyl-1,3,4-thiadiazoles

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