New Polyacetylenes, DGAT Inhibitors from the Roots of Panax ginseng

Abstract

The petroleum ether extract of Panax ginseng showed a significant inhibition of the diacylglycerol acyltransferase (DGAT) enzyme from rat liver microsomes. Bioactivity-guided fractionation led to the isolation of two new polyacetylenic compounds, (9R,10S)-epoxyheptadecan-4,6-diyn-3-one (1) and 1-methoxy-(9R,10S)-epoxyheptadecan-4,6-diyn-3-one (2). Their chemical structures were elucidated on the basis of spectroscopic evidence and asymmetric synthesis. IC₅₀ values of 9 μg/mL (1) and 32 μg/mL (2) were obtained.

Key words

Panax ginseng - Araliaceae - diacylglycerol acyltransferase (DGAT) - polyacetylenes - structure elucidation

References

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