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Exp Clin Endocrinol Diabetes 2004; 112(1): 38-43
DOI: 10.1055/s-2004-815725
Article

J. A. Barth Verlag in Georg Thieme Verlag Stuttgart · New York

Concentration of Insulin-Like Growth Factor (IGF)-I in Iliac Crest Bone Matrix in Premenopausal Women with Idiopathic Osteoporosis

C. E. Pepene 1 , 5 , T. Seck 1 , I. Diel 2 , H. W. Minne 3 , R. Ziegler 1 , J. Pfeilschifter 4
  • 1Department of Internal Medicine I, University of Heidelberg, Germany
  • 2Department of Gynecology, University of Heidelberg, Germany
  • 3Klinik „Der Fürstenhof“, Bad Pyrmont, Germany
  • 4Department of Medicine, BG-Kliniken Bergmannsheil, University of Bochum, Germany
  • 5Department of Endocrinology, University of Medicine and Pharmacy Cluj-Napoca, Romania
Further Information

Publication History

Received: December 16, 2002 First decision: February 20, 2003

Accepted: April 22, 2003

Publication Date:
03 February 2004 (online)

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Abstract

Previous studies have shown a link between low serum insulin-like growth factor-I (IGF-I) and decreased bone mass of patients with osteoporosis. However, whether serum levels are representative for the growth factor concentration or activity available in human bone tissue is controversial. In the present study, IGF-I was assessed in serum and bone matrix extracts from the iliac crest in 19 eugonadal women with idiopathic osteoporosis and in 38 age-matched controls. In addition, the relationship between the skeletal levels of IGF-I and bone mineral density (BMD) or the susceptibility to osteoporotic fractures in women with osteoporosis was examined. Bone matrix extraction was performed based on a guanidine-HCL/ethylendiamine-tetraacetic acid (EDTA) method. No significant difference in both serum and bone matrix IGF-I levels between groups was observed. Serum IGF-I concentrations failed to be associated with bone matrix IGF-I levels in osteoporotic patients. However, in premenopausal women with idiopathic osteoporosis, skeletal IGF-I positively correlated with BMD at the lumbar spine (r = + 0.58, p = 0.01). In contrast, neither femoral neck BMD nor Ward's triangle BMD was associated with bone matrix IGF-I concentrations. A tendency towards lower levels of bone matrix IGF-I in subjects with vertebral fractures as compared to those without fractures was observed in age-adjusted analyses, however the difference failed to remain statistically significant after adjustment for bone mineral density. These data provide no clear evidence for low bone matrix IGF-I as a determinant factor of age-unrelated osteoporosis. However, low skeletal IGF-I concentrations may aggravate osteoporosis in these women.

Key words

Insulin-like growth factor-I - osteoporosis - bone matrix - bone mineral density

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